Evaluation of Biological Aging Process - A Population-Based Study of Healthy People in China
Evaluation of Biological Aging Process - A Population-Based Study of Healthy People in China
复制标题
DOI：
10.1159/000262449
复制
发表时间：
2010-01-01
期刊：
影响因子：
3.5
通讯作者：
Chen, Xiang-mei
中科院分区：
文献类型：
--
作者：
Bai, Xiaojuan;Han, Lulu;Chen, Xiang-mei
背景资料：虽然已经有横断面和纵向研究检查生物学年龄（BA）与实际年龄（CA）相关的身体，生理，生化和激素变量的变化，很少有研究进行心血管系统和炎症生物标志物的超声心动图评价。此外，对中国健康人群的衰老生物标志物和BA评分（BAS）知之甚少。目的：本研究的目的是确定健康老龄化的生物标志物，并建立中国健康人群的BAS。研究方法：我们对中国三个城市的2,876名30-98岁的男性和女性进行了检查，并对852名健康受试者进行了108项身体，形态，生理和生化变量的评估。排除二元变量后，与CA相关系数≥ 75岁的变量。结论：我们的数据表明，BAS在评估中国健康人群的衰老率方面优于CA上级。心血管变量在评估生物老化中起着至关重要的作用。生物老化率似乎是年龄特异性的。版权所有（C）2009 S. Karger AG，巴塞尔
Background: Although there have been cross-sectional and longitudinal studies examining biological age (BA) with chronological age (CA)-related changes in physical, physiological, biochemical, and hormonal variables, few studies have performed echocardiographic evaluation of the cardiovascular system and inflammatory biomarkers. Furthermore, little is known about biomarkers of aging and BA score (BAS) for healthy people in China. Objectives: The purpose of this study was to identify the biomarkers of healthy aging and to establish BAS for healthy people in China. Methods: We examined 2,876 men and women aged 30-98 years old in three Chinese cities, and 852 healthy subjects were assessed with 108 physical, morphological, physiological and biochemical variables. After excluding binary variables, variables that had a correlation coefficient with CA of = 75 years of age. Conclusions: Our data suggest that BAS is superior to CA in assessing the rate of aging in healthy Chinese people. The cardiovascular variables play a crucial role in the evaluation of biological aging. Biological aging rate appears to be age specific. Copyright (C) 2009 S. Karger AG, Basel