Sleep and endocrine therapy in breast cancer.
Sleep and endocrine therapy in breast cancer.
复制标题
DOI：
10.1016/j.coemr.2021.03.007
复制
发表时间：
2021-06
影响因子：
--
通讯作者：
Carroll JE
中科院分区：
文献类型：
--
作者：
Van Dyk K;Joffe H;Carroll JE
睡眠障碍和失眠在乳腺癌幸存者中很常见，并可能对生活质量和许多其他重要结果产生重大影响。睡眠障碍的风险之一是引入抗雌激素内分泌疗法。在内分泌治疗中，导致睡眠障碍的可能因素是复杂的，包括先前存在的睡眠障碍、化疗和其他治疗的影响，以及同时出现的症状，如潮热。此外，更年期的睡眠障碍是一种常见的现象，这是老年生殖激素的自然下调，可以为了解接受内分泌治疗的乳腺癌幸存者睡眠问题的高发情况提供一个模型，并建议可能的治疗方法，如行为干预和药物治疗。总之，需要更多的研究来更好地了解和解决乳腺癌幸存者的内分泌治疗中的睡眠障碍，以支持生活质量和治疗依从性。
Sleep disturbances and insomnia are common among breast cancer survivors, and can have a significant effect on quality of life and numerous other significant outcomes. Among risks for sleep disturbance is the introduction of anti-estrogen endocrine therapies. The possible contributing factors to sleep disturbance in endocrine therapy are complex, and include pre-existing sleep disorders, the effects of chemotherapy and other treatments, and concurrent symptoms such as hot flashes. In addition, sleep disturbance in menopause, the natural downregulation of reproductive hormones in older age, is a common occurrence, and can offer a model for understanding the high prevalence of sleep problems in breast cancer survivors on endocrine therapy, as well as suggesting possible treatments such as behavioral interventions and pharmaceuticals. Altogether, significantly more research is needed to better understand and address sleep disturbance in breast cancer survivors on endocrine therapy in order to support quality of life and treatment adherence.