Chiral porous hybrid solids for practical heterogeneous asymmetric hydrogenation of aromatic ketones
Chiral porous hybrid solids for practical heterogeneous asymmetric hydrogenation of aromatic ketones
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DOI：
10.1021/ja0348344
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发表时间：
2003-09-24
影响因子：
15
通讯作者：
Lin, WB
中科院分区：
文献类型：
--
作者：
Hu, AG;Ngo, HL;Lin, WB
通过分子积木法合成了含有Ru−BINAP−DPEN结构的手性多孔膦酸锆，并通过TGA、吸附等温线、XRD、SEM、IR和微量分析等技术对其进行了表征。这些混合固体用于芳香酮的对映选择性非均相不对称氢化，具有高达99.2%的显着高ee值。这些固体催化剂也可以很容易地回收和重复使用8次而不损失活性和对映选择性。这种分子构建块方法的可调谐性将允许优化这些混合材料，并有望导致其他实际有用的非均相不对称催化剂。
Chiral porous zirconium phosphonates containing Ru−BINAP−DPEN moieties were synthesized via a molecular building-block approach, and characterized by a variety of techniques including TGA, adsorption isotherms, XRD, SEM, IR, and microanalysis. These hybrid solids were used for enantioselective heterogeneous asymmetric hydrogenation of aromatic ketones with remarkably high ee values of up to 99.2%. These solid catalysts can also be easily recycled and reused for eight times without the loss of activity and enantioselectivity. Ready tunability of such a molecular building-block approach will allow the optimization of these hybrid materials and promise to lead to other practically useful heterogeneous asymmetric catalysts.