Interleukin (IL)-1A and IL-6: Applications to the predictive diagnostic testing of radiation pneumonitis
Interleukin (IL)-1A and IL-6: Applications to the predictive diagnostic testing of radiation pneumonitis
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DOI：
10.1016/j.ijrobp.2005.01.041
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发表时间：
2005-05-01
影响因子：
7
通讯作者：
Rubin, P
中科院分区：
文献类型：
--
作者：
Chen, YY;Hyrien, O;Rubin, P
目的：探讨白细胞介素1α(IL-1α)和白细胞介素6(IL-6)测定在放射性肺炎(RP)预测诊断中的应用。方法与材料：采用前瞻性研究方法，采用酶联免疫吸附试验(EIA)对胸部放射治疗患者每周连续采血进行IL-1α和IL-6测定。我们分析了两种细胞因子在诊断试验中的灵敏度、特异度、阳性预测值(PPV)和阴性预测值(NPV)。结果：每周平均IL-1α水平的变异系数为51%，每周平均IL-6水平的变异系数为39%。IL-1α和IL-6与时间呈正相关。两种细胞因子的特异性均好于敏感性。IL-6在预测RP方面总体上优于IL-1α，PPV和NPV较高。结论：我们的数据证实了应用血液标本IL-1α和IL-6来预测RP的可行性。IL-6检测比IL-1α检测具有更强的阳性预测值。这一应用可能会在更大的患者样本中进一步探索。(C)2005年爱思唯尔公司。
Purpose: To explore the application of interleukin (IL)-1 alpha and IL-6 measurements in the predictive diagnostic testing for symptomatic radiation pneumonitis (RP).Methods and Materials: In a prospective protocol investigating RP and cytokines, IL-1 alpha and IL-6 values were analyzed by enzyme-linked immunosorbent assay from serial weekly blood samples of patients receiving chest radiation. We analyzed sensitivity, specificity, positive predictive value (PPV), and negative predictive value (NPV) over selected threshold values for both cytokines in the application to diagnostic testing.Results: The average coefficient of variation was 51% of the weekly mean IL-1 alpha level and 39% of the weekly mean IL-6 value. Interleukin 1 alpha and IL-6 became positively correlated with time. Specificity for both cytokines was better than sensitivity. IL-6 globally outperformed IL-1 alpha in predicting RP, with higher PPV and NPV.Conclusions: Our data demonstrate the feasibility of applying IL-1 alpha and IL-6 measurements of blood specimens to predict RP. Interleukin-6 measurements offer stronger positive predictive value than IL-1 alpha. This application might be further explored in a larger sample of patients. (c) 2005 Elsevier Inc.