Genetic determination of bacterial virulence, with special reference to Salmonella.
Genetic determination of bacterial virulence, with special reference to Salmonella.
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DOI：
10.1007/978-3-642-70986-9_9
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发表时间：
1986
影响因子：
--
通讯作者：
B. Stocker;P. Mäkelä
中科院分区：
文献类型：
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作者：
B. Stocker;P. Mäkelä
“毒力因子”或“毒力决定子”通常用于指细菌性状，例如阻碍吞噬作用的表面成分的产生，其存在被注意到与毒力相关，并且其通过突变等的损失导致实验系统中毒力的损失或大大降低。从逻辑上讲，细菌在宿主相关区室中生长所必需的任何细菌特性，例如在普遍温度下生长的能力，都应被视为毒力因子；我们将讨论这些特性，以及那些通常称为毒力因子的特性。为了在宿主组织中生存，病原菌必须能够承受宿主防御微生物或其他外来物质的反应。其中一种防御就是吞噬作用。这似乎很可能是从真核生物的基本摄食行为进化而来的，就像现在在变形虫中看到的那样。在多细胞生物体中，例如人和小鼠，这种防御被委托给几种特殊的细胞，
" Virulence factor" or" virulence determinant" is often used to refer to bacterial traits, such as production of a surface component hindering phagocytosis, whose presence is noted to be correlated with virulence and whose loss, by mutation, etc., causes loss or great reduction in virulence in an experimental system. Logically any bacterial property indispensable for bacterial growth in the relevant compartment of the host, such as ability to grow at the temperature there prevalent, should be considered a virulence factor; we shall discuss such properties, as well as those commonly called virulence factors. To survive in the tissue of a host, a pathogenic bacterium must be able to withstand the responses by which the host defends itself against microorganisms or other foreign material. One such defense is phagocytosis; it seems very likely that this evolved from the basic feeding behavior of eukaryotic organisms, as now seen in, for instance, the amoebae. In multicellular organisms, such as man and mouse, this defense is entrusted to specialized cells of several kinds,