An evaluation of the immune response of deer mice to Sin Nombre virus
An evaluation of the immune response of deer mice to Sin Nombre virus
复制标题
鹿鼠对 Sin Nombre 病毒免疫反应的评估
DOI：
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发表时间：
2012
期刊：
影响因子：
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通讯作者：
E. Lehmer
中科院分区：
文献类型：
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作者：
Ashley Kelly;E. Molinar;Joni Ghachu;Lacey Hart;Colleen;O’Brien;K. Wright;T. Schountz;Cathy Hartney;E. Lehmer
新诺布雷病毒(SNV)在人类中引起汉坦病毒肺综合征(HPS)，是一种死亡率高(~36%)的疾病。鹿鼠是新城疫病毒的主要宿主，与人类不同，感染新城疫病毒的鹿鼠几乎没有明显的疾病迹象。鹿鼠受到如此轻微感染的原因还没有得到很好的研究；然而，这些信息可能有助于揭示可以降低人类HPS死亡率的治疗方法。因此，本研究的目的是通过检测鹿小鼠的白细胞产生模式来评价鹿小鼠对SNV的免疫应答。我们量化了野鹿鼠在SNV感染的早期和晚期产生的淋巴细胞、嗜酸性粒细胞、嗜碱性粒细胞、中性粒细胞和单核细胞的数量。与在季末捕获的鹿鼠相比，在早期捕获的鹿鼠具有更高的嗜碱性细胞、淋巴细胞和嗜酸性粒细胞水平。相反，在晚季捕获的鹿鼠中，单核细胞水平更高。SNV感染状态似乎同时影响中性粒细胞和单核细胞的产生，SNV感染的小鼠的中性粒细胞水平高于未感染的小鼠，但单核细胞水平低于未感染的小鼠。总体而言，这些结果似乎支持这样一种观点，即野生鹿鼠面临的免疫应激源从季节的早期转移到季节的晚期，这些差异反映在不同季节发生的白细胞产生的差异上。此外，我们的结果表明，野生鹿小鼠和实验室饲养的鹿小鼠之间存在一些潜在的差异，以及野生鹿小鼠和人类在对SNV感染的免疫反应方面可能有一些相似之处。
Sin Nombre virus (SNV) causes hantavirus pulmonary syndrome (HPS) in humans, a disease with high (~36%) mortality. Deer mice (Peromyscus maniculatus) are the primary host of SNVand, unlike humans, deer mice infected with SNV have few overt signs of disease. The reasons for such mild infections in deer mice have not been well studied; however, this information may be useful in uncovering therapies that could reduce human HPSmortality. Therefore, the objective of this study was to evaluate the immune response of deer mice to SNV by examining their patterns of white blood cell production. We quantified the number of lymphocytes, eosinophils, basophils, neutrophils, and monocytes produced by wild deer mice in both the early and late stages of SNV infection. Deer mice captured in the early season had greater basophil, lymphocyte, and eosinophil levels compared to deer mice captured in the late season. Conversely, monocyte levels were greater in deer mice captured in the late season. SNV infection status appeared to influence production of both neutrophils and monocytes, with SNV-infected mice having greater neutrophil levels but lower monocyte levels than uninfected mice. Collectively, the results seem to support the notion that immune stressors faced by wild deer mice shift from early to late season, and these differences are reflected by differential leukocyte production that occurs across seasons. Furthermore, our results indicate some potential differences between wild deer mice and lab-bred deer mice, as well as some possible similarities between wild deer mice and humans in their immune responses to SNV infection.
影响因子：
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作者：
G. Gleich;C. Adolphson
通讯作者：
G. Gleich;C. Adolphson
影响因子：
6
作者：
S. Zaki;P. Greer;L. Coffield;C. Goldsmith;K. B. Nolte;K. Foucar;R. Feddersen;R. Zumwalt;G. Miller;Ali S Khan;P. Rollin;T. Ksiazek;S. Nichol;B. Mahy;C. Peters
通讯作者：
S. Zaki;P. Greer;L. Coffield;C. Goldsmith;K. B. Nolte;K. Foucar;R. Feddersen;R. Zumwalt;G. Miller;Ali S Khan;P. Rollin;T. Ksiazek;S. Nichol;B. Mahy;C. Peters