BROWN ADIPOSE TISSUE AND HEAT PRODUCTION IN NEWBORN INFANT
BROWN ADIPOSE TISSUE AND HEAT PRODUCTION IN NEWBORN INFANT
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DOI：
10.1002/path.1700910126
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发表时间：
1966-01-01
期刊：
影响因子：
--
通讯作者：
HULL, D
中科院分区：
文献类型：
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作者：
AHERNE, W;HULL, D
研究了新生儿棕色脂肪组织的分布和组织学外观。主要的棕色脂肪块位于纵隔或腹部深处，但重要的脂肪块存在于肩胛间、腋窝和颈部区域。未成熟的棕色脂肪位点可能在未存活的婴儿中被发现；这些位点可能已经含有完整的脂肪细胞。随着婴儿成熟至足月，每个细胞的细胞质体积大幅增加，并且伴随着由于线粒体增殖而导致的粒度增加。在死后检查的婴儿出生后的最初几天里，棕色脂肪组织的脂肪含量逐渐下降。早产儿的发病率高于成熟婴儿。糖尿病母亲的婴儿在此期间保持较高的脂肪含量。在死于寒冷综合症的婴儿和两名被诊断为体温过低的老年人中，发现棕色脂肪组织完全耗尽。给出了不将棕色脂肪组织视为白色脂肪组织发育阶段而是将其视为成熟的特定组织的理由，其功能是产生热量。
The distribution and histological appearance of brown adipose tissue in the newborn infant were studied. The main brown adipose masses are situated deeply, in the mediastinum or abdomen, but important masses are present in the interscapular, axillary and cervical regions. Immature brown adipose sites may be identified in pre-viable infants; such sites probably already contain their full complement of adipose cells. As the infant matures to term a large increase occurs in the volume of cytoplasm per cell, and this is accompanied by increasing granularity due to the multiplication of mitochondria. There is a progressive fall in the fat content of brown adipose tissue in the first few days of life in infants examined post mortem. It is greater in premature than in mature infants. The infants of diabetic mothers maintained a high fat content over this period. Total depletion of brown adipose tissue was found in babies dead of the cold syndrome and in 2 elderly adults who were admitted with a diagnosis of hypothermia. Reasons are given for regarding brown adipose tissue not as a phase in the development of white adipose tissue but as a mature specific tissue the function of which is the production of heat.