Change in cartilage morphometry: a sample of the progression cohort of the Osteoarthritis Initiative
Change in cartilage morphometry: a sample of the progression cohort of the Osteoarthritis Initiative
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DOI：
10.1136/ard.2007.082107
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发表时间：
2009-03-01
影响因子：
27.4
通讯作者：
Beals, C. R.
中科院分区：
文献类型：
--
作者：
Hunter, D. J.;Niu, J.;Beals, C. R.
目的：在广泛应用该技术之前，需要准确描述磁共振成像（MRI）透明关节软骨测量的性能特征。我们的目的是评估来自骨关节炎倡议 (OAI) 的一部分参与者中患有骨关节炎 (OA) 的膝盖从基线到 1 年的软骨形态计量学测量的自然疾病进展率。方法：本次探索性分析的受试者是 OAI 研究中约 4700 名参与者的一部分。所有参与者均在基线和每年获得膝盖的双侧 X 光片和 3T MRI（Siemans Trio）以及临床数据。来自 OAI 进展亚组的 160 名受试者均具有频繁出现的症状，并且在同一膝关节中，根据在 OAI 诊所进行的筛查读数，进行了放射线 OA，有资格进行这项探索性分析。选择每个受试者的一个膝盖进行分析。共有 150 名参与者。使用来自基线和 12 个月随访的矢状 3D DESSwe（双回波、水激励稳态序列）MR 图像，将分割算法应用于索引膝关节的软骨板，以计算软骨体积、归一化软骨体积（归一化至骨表面界面面积的体积）和裸露面积百分比（裸露的总软骨骨界面面积） 结果：计算 1 年时相对于基线的变化（绝对值和百分比）和标准化反应平均值 (SRM)（即平均变化除以 SD 变化）的汇总统计。受试者平均年龄为 60.9 岁，肥胖，平均体重指数为 30.3 kg/m(2)。各个位置的软骨体积的SRM为：中央胫骨内侧-0.096；股骨内侧中央-0.394；和髌骨-0.198。各个位置的标准化软骨体积的 SRM 为胫骨内侧中央 -0.044、股骨内侧中央 -0.338 和髌骨 -0.193。大多数参与者在基线时股骨内侧中央（62%）和胫骨内侧中央（60%）有裸露区域。一般来说，SRM 较小。 结论：这些软骨形态测定的描述性结果及其在 OAI 进展亚组首次发布实质性 MRI 数据后 1 年时间点的变化表明，年化变化率较小，股骨内侧中央显示出最大的一致变化。
Objective: The performance characteristics of hyaline articular cartilage measurement on magnetic resonance imaging (MRI) need to be accurately delineated before widespread application of this technology. Our objective was to assess the rate of natural disease progression of cartilage morphometry measures from baseline to 1 year in knees with osteoarthritis (OA) from a subset of participants from the Osteoarthritis Initiative (OAI).Methods: Subjects included for this exploratory analysis are a subset of the approximately 4700 participants in the OAI Study. Bilateral radiographs and 3T MRI (Siemans Trio) of the knees and clinical data were obtained at baseline and annually in all participants. 160 subjects from the OAI Progression subcohort all of whom had both frequent symptoms and, in the same knee, radiographic OA based on a screening reading done at the OAI clinics were eligible for this exploratory analysis. One knee from each subject was selected for analysis. 150 participants were included. Using sagittal 3D DESSwe ( double echo, steady-state sequence with water excitation) MR images from the baseline and 12 follow-up month visit, a segmentation algorithm was applied to the cartilage plates of the index knee to compute the cartilage volume, normalised cartilage volume ( volume normalised to bone surface interface area), and percentage denuded area ( total cartilage bone interface area denuded of cartilage).Results: Summary statistics of the changes ( absolute and percentage) from baseline at 1 year and the standardised response mean (SRM), ie, mean change divided by the SD change were calculated. On average the subjects were 60.9 years of age and obese, with a mean body mass index of 30.3 kg/m(2). The SRMs for cartilage volume of various locations are: central medial tibia -0.096; central medial femur -0.394; and patella -0.198. The SRMs for normalised cartilage volume of the various locations are central medial tibia -0.044, central medial femur -0.338 and patella -0.193. The majority of participants had a denuded area at baseline in the central medial femur (62%) and central medial tibia (60%). In general, the SRMs were small.Conclusions : These descriptive results of cartilage morphometry and its change at the 1-year time point from the first substantive MRI data release from the OAI Progression subcohort indicate that the annualised rates of change are small with the central medial femur showing the greatest consistent change.