MRI abnormalities following febrile status epilepticus in children The FEBSTAT study
MRI abnormalities following febrile status epilepticus in children The FEBSTAT study
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DOI：
10.1212/wnl.0b013e318266fcc5
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发表时间：
2012-08-01
期刊：
影响因子：
9.9
通讯作者：
Sun, Shumei
中科院分区：
文献类型：
--
作者：
Shinnar, Shlomo;Bello, Jacqueline A.;Sun, Shumei
目的：FEBSTAT研究是一项前瞻性研究，旨在确定儿童期发热性癫痫持续状态（FSE）的急性和长期后果。方法：从2003年至2010年，199名1个月至5岁的儿童在FSE发作后72小时内入选FEBSTAT。其中，191人进行了海马体成像。所有MRI均由2名对临床细节不知情的神经放射科医生进行审查。一组的96名儿童首次简单FS谁使用类似的协议成像作为controls.Results：共22（11.5%）的儿童有明确的异常（n = 17）或可疑（n = 5）增加T2信号在海马FSE与对照组相比，没有（P < 0.0001）。海马发育异常在FSE组（n = 20，10.5%）中比对照组（n = 2，2.1%）更常见（p = 0.0097），其中海马旋转不良最常见（15例病例和2例对照）。FSE组和对照组中分别有15.7%和15.6%出现海马外成像异常。然而，颞叶的海马外成像异常更常见的FSE组（7.9%）比对照组（1.0%）（p = 0.015）。结论：这项前瞻性研究表明，FSE的儿童有急性海马损伤的风险，大量的海马发育异常。后续研究正在进行中，以确定这些儿童的长期结果。神经病学（R）2012;79：871-877
Objective: The FEBSTAT study is a prospective study that seeks to determine the acute and long-term consequences of febrile status epilepticus (FSE) in childhood.Methods: From 2003 to 2010, 199 children age 1 month to 5 years presenting with FSE (>30 minutes) were enrolled in FEBSTAT within 72 hours of the FSE episode. Of these, 191 had imaging with emphasis on the hippocampus. All MRIs were reviewed by 2 neuroradiologists blinded to clinical details. A group of 96 children with first simple FS who were imaged using a similar protocol served as controls.Results: A total of 22 (11.5%) children had definitely abnormal (n = 17) or equivocal (n = 5) increased T2 signal in the hippocampus following FSE compared with none in the control group (p < 0.0001). Developmental abnormalities of the hippocampus were more common in the FSE group (n = 20, 10.5%) than in controls (n = 2, 2.1%) (p = 0.0097) with hippocampal malrotation being the most common (15 cases and 2 controls). Extrahippocampal imaging abnormalities were present in 15.7% of the FSE group and 15.6% of the controls. However, extrahippocampal imaging abnormalities of the temporal lobe were more common in the FSE group (7.9%) than in controls (1.0%) (p = 0.015).Conclusions: This prospective study demonstrates that children with FSE are at risk for acute hippocampal injury and that a substantial number also have abnormalities in hippocampal development. Follow-up studies are in progress to determine the long-term outcomes in these children. Neurology (R) 2012;79:871-877