Toxicity of gold nanoparticles functionalized with cationic and anionic side chains
Toxicity of gold nanoparticles functionalized with cationic and anionic side chains
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DOI：
10.1021/bc049951i
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发表时间：
2004-07-01
影响因子：
4.7
通讯作者：
Rotello, VM
中科院分区：
文献类型：
--
作者：
Goodman, CM;McCusker, CD;Rotello, VM
金纳米颗粒的结构和性质使其可用于广泛的生物应用。然而，使用这些系统在高浓度下观察到毒性。使用MTT、溶血和细菌活力测定来探索使用的细胞类型之间的差异毒性，使用2nm核心颗粒。这些研究表明，阳离子颗粒是中等毒性的，而阴离子颗粒是相当无毒的。在使用脂质囊泡的染料释放研究中观察到由初始静电结合介导的浓度依赖性裂解，为观察到的阳离子MMPC毒性提供了可能的机制。
The structure and properties of gold nanoparticles make them useful for a wide array of biological application. Toxicity, however, has been observed at high concentrations using these systems. MTT, hemolysis, and bacterial viability assays were used to explore differential toxicity among the cell types used, using 2 nm core particles. These studies show that cationic particles are moderately toxic, whereas anionic particles are quite nontoxic. Concentration-dependent lysis mediated by initial electrostatic binding was observed in dye release studies using lipid vesicles, providing the probable mechanism for observed toxicity with the cationic MMPCs.