HERITABILITY OF CORTISOL RESPONSES TO HUMAN CORTICOTROPIN-RELEASING HORMONE, ERGOMETRY, AND PSYCHOLOGICAL STRESS IN HUMANS
HERITABILITY OF CORTISOL RESPONSES TO HUMAN CORTICOTROPIN-RELEASING HORMONE, ERGOMETRY, AND PSYCHOLOGICAL STRESS IN HUMANS
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DOI：
10.1210/jcem.75.6.1464659
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发表时间：
1992-12-01
影响因子：
5.8
通讯作者：
HELLHAMMER, DH
中科院分区：
文献类型：
--
作者：
KIRSCHBAUM, C;WUST, S;HELLHAMMER, DH
本研究调查了皮质醇对三种不同刺激程序的反应，重点是遗传因素的贡献。13个同卵（MZ）双胞胎对和11个异卵（DZ）双胞胎对进行自行车测力计，直到筋疲力尽，并暴露在公众面前演讲和心算的心理压力。此外，9个MZ对和10个DZ对注射100 μ g合成人CRH（HCRH）。肾上腺皮质对这些挑战的反应是通过测定唾液中的皮质醇来监测的，在女性中发现了基线皮质醇水平的显著个体内稳定性，但在男性中较少。最大的皮质醇反应，所有三个刺激程序显着相互关联的男性，但在女性中，只有皮质醇反应HRH和测力计运动表现出显着的相关性。虽然遗传因素的决定性影响，观察到所有三个基线皮质醇水平以及对HRH的反应，遗传似乎是发挥次要作用的肾上腺皮质对心理压力的反应。自行车运动后皮质醇的变化表明，遗传因素对剧烈运动后皮质醇的分泌没有影响。
The present study investigated cortisol responses to three different stimulation procedures, with a focus on the contribution of genetic factors. Thirteen monozygotic (MZ) twin pairs and 11 dizygotic (DZ) twin pairs performed bicycle ergometry until exhaustion and were exposed to the psychological stress of public speaking and mental arithmetic in front of an audience. Furthermore, 9 MZ pairs and 10 DZ pairs were injected with 100 mug synthetic human CRH (HCRH). The adrenocortical response to these challenges was monitored by determination of cortisol in saliva.Significant intraindividual stability of baseline cortisol levels was found in females, but was less in males. Maximum cortisol responses to all three stimulation procedures were significantly intercorrelated in males, but in females only the cortisol responses to HCRH and ergometer exercise showed a significant correlation. While a decided influence of genetic factors was observed for all three baseline cortisol levels as well as for the response to HCRH, heredity appeared to be play a minor role in the adrenocortical response to psychological stress. Cortisol changes after bicycle ergometry revealed no impact of genetic factors on the secretion of cortisol in response to strenuous physical exercise.