SEVERITY OF DIABETIC MACULAR EDEMA CORRELATES WITH RETINAL VASCULAR BED AREA ON ULTRA-WIDE FIELD FLUORESCEIN ANGIOGRAPHY DAVE Study
SEVERITY OF DIABETIC MACULAR EDEMA CORRELATES WITH RETINAL VASCULAR BED AREA ON ULTRA-WIDE FIELD FLUORESCEIN ANGIOGRAPHY DAVE Study
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DOI：
10.1097/iae.0000000000002579
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发表时间：
2020-06-01
影响因子：
3.3
通讯作者：
Ip, Michael
中科院分区：
文献类型：
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作者：
Fan, Wenying;Uji, Akihito;Ip, Michael
目的：通过超宽视场荧光素血管造影定量测定糖尿病性黄斑水肿（DME）患者视网膜非灌注面积和视网膜血管床面积（RVBA） （mm(2)），并探讨其与DME严重程度的关系。方法：前瞻性观察性病例系列。参与DAVE研究（NCT01552408）的29例初治DME患者的40只眼睛的基线超宽视场荧光素血管造影图像在Doheny图像阅读中心进行立体投影。自动提取视网膜血管，计算RVBA。非灌注区域由两名经过认证的蒙面分级机人工圈定。通过调节外周畸变，自动计算视网膜血管床面积和非灌注面积（mm(2)），并与DME的严重程度相关联。结果：与健康对照组相比，DME患者全视网膜RVBA (54.7 +/- 16.6 mm（2) vs. 37.2 +/- 9.9 mm(2), P < 0.001）增加，且与DME严重程度相关（P < 0.05）。视网膜缺血（非灌注区）分布不均匀，与DME程度无关（P < 0.05）。结论：与健康对照相比，DME组眼RVBA升高。DME的严重程度似乎与整体RVBA有关，但与视网膜缺血无关。
Purpose: To quantify retinal nonperfusion area and retinal vascular bed area (RVBA) in mm(2) on ultra-widefield fluorescein angiography in eyes with diabetic macular edema (DME) and explore their relationship with the severity of DME. Methods: Prospective, observational case series. Baseline ultra-widefield fluorescein angiography images of 40 eyes from 29 patients with treatment-naive DME who participated in the DAVE study (NCT01552408) were stereographically projected at Doheny Image Reading Center. The retinal vasculature was automatically extracted to calculate RVBA. Nonperfusion area was manually delineated by two masked certified graders. Retinal vascular bed area and nonperfusion area were computed in mm(2) automatically by adjusting for peripheral distortion and then correlated with the severity of DME. Results: The global RVBA for the entire retina in eyes with DME was increased compared with healthy controls (54.7 +/- 16.6 mm(2) vs. 37.2 +/- 9.9 mm(2), P < 0.001) and correlated with the severity of DME (P < 0.05). Retinal ischemia (nonperfusion area) was nonuniformly distributed and not related to DME extent (P > 0.05). Conclusion: Eyes with DME have an increased RVBA compared with healthy controls. The severity of DME appears to be related to global RVBA, but not to retinal ischemia.