Photochemically Assisted Introduction of a Benzyl Unit into Isoquinolines Using Benzyltrifluoroborates
Photochemically Assisted Introduction of a Benzyl Unit into Isoquinolines Using Benzyltrifluoroborates
复制标题
DOI：
10.1246/cl.160762
复制
发表时间：
2016-10
影响因子：
1.6
通讯作者：
Y. Nishigaichi;Takayuki Orimi;Kuniyoshi Koyachi;Yuuki Ohmuro;Masaaki Suzuki
中科院分区：
文献类型：
--
作者：
Y. Nishigaichi;Takayuki Orimi;Kuniyoshi Koyachi;Yuuki Ohmuro;Masaaki Suzuki
在氯甲酸甲酯存在下，用三氟硼酸苄酯试剂对异喹啉的 1 位进行光化学苄基化。当使用被给电子基团取代的苄基时，苄基化反应通过热进行。本反应可以直接合成苄基异喹啉生物碱的骨架。
Isoquinoline was photochemically benzylated at its 1 position with benzyltrifluoroborate reagents in the presence of methyl chloroformate. When a benzyl group substituted by an electron-donating group was employed, the benzylation thermally proceeded. The present reaction allowed straightforward synthesis of the skeleton for the benzylisoquinoline alkaloid.