Oxygenated Cembranoids from the Cultured and Wild-Type Soft Corals Sinularia flexibilis
Oxygenated Cembranoids from the Cultured and Wild-Type Soft Corals Sinularia flexibilis
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DOI：
10.1248/cpb.57.1189
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发表时间：
2009-11-01
影响因子：
1.7
通讯作者：
Sheu, Jyh-Horng
中科院分区：
文献类型：
--
作者：
Su, Jui-Hsin;Lin, Yu-Fang;Sheu, Jyh-Horng
从软珊瑚Sinularia flexibilis中分离得到两个新的西松烷类化合物：flexibilisolide A（1）和flexibilisin A（2），沿着一个已知的合松烷类化合物5。此外，从野生软珊瑚S中分离到两个新的西松烷类化合物，flexibilisolide B（3）和flexibilisin B（4），沿着两个已知的combranoids（5，6）。柔韧性新代谢物的结构是在广泛的光谱分析的基础上，并通过与已知化合物的NMR数据进行比较来确定的。代谢物5和6显示出对MCF-7癌细胞系的弱细胞毒活性。
Two new cembranoids, flexibilisolide A (1) and flexibilisin A (2), along with one known combranoid 5 have been isolated from the cultured soft coral Sinularia flexibilis. Furthermore, two new cembranoids, flexibilisolide B (3) and flexibilisin B (4), along with two known combranoids (5, 6), have been isolated from the wild-type soft coral S. flexibilis. The structures of the new metabolites were determined on the basis of extensive spectroscopic analysis and by comparison of NMR data with those of known compounds. The metabolites 5 and 6 have been shown to exhibit weak cytotoxic activity against MCF-7 cancer cell line.