Prospective study of factors important to achieve observation of the entire colon on colon capsule endoscopy.
Prospective study of factors important to achieve observation of the entire colon on colon capsule endoscopy.
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DOI：
10.1177/1756283x16673556
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发表时间：
2017-01
影响因子：
4.2
通讯作者：
Hirooka Y
中科院分区：
文献类型：
--
作者：
Sato J;Nakamura M;Watanabe O;Yamamura T;Funasaka K;Ohno E;Miyahara R;Kawashima H;Goto H;Hirooka Y
结肠胶囊内窥镜检查(CCE)是一种吞咽胶囊以便于观察整个消化道管腔的过程。与传统的结肠镜检查(CS)相比，它不需要空气供应，是一种非侵入性手术，不良事件的风险明显较低。它减轻了患者的压力，并可能为患者所接受。该方法的局限性是整个结肠观察率(CCE排泄率、完全CCE排泄率)不是100%。在这项研究中，我们前瞻性地调查了在CCE上实现全结肠观察的重要临床因素。参与者是70名患者，他们被安排接受CCE，并从他们那里获得了关于参与这项研究的书面知情同意。我们选择了患者背景/检查因素，并用多因素分析分析了全结肠观察所涉及的所有因素以及检查开始后4小时内完成CCE的因素。经多因素Logistic回归分析，只有检查时⩾12.0ml/m in的饮水量[P=0.025，优势比(OR)：46.753，95%可信区间(CI)：1.630~1.630]是影响全结肠观察的独立预测因素。多因素Logistic回归分析显示，⩾25(p=0.039，OR：13.723，95%CI：1.135~165.913)、无便秘(p=0.030，OR：13.988，95%CI：1.287~152.047)、检查时⩾摄入量12.0ml/m in(p=0.004，OR：12.028，95%CI：2.225~65.029)是独立的预测因素。CCE的完成与每小时的水摄入量关系最密切。除了水的摄入，促进CCE的因素还包括高BMI和没有便秘。
Colon capsule endoscopy (CCE) is a procedure in which capsule swallowing facilitates observation of the lumen of the entire digestive tract. It does not require an air supply, and is a noninvasive procedure with a markedly low risk of adverse events in comparison with conventional colonoscopy (CS). It reduces patient stress, and may be acceptable to patients. A limitation of this procedure is that the entire colon observation rate (CCE excretion rate, completed CCE rate) is not 100%. In this study, we prospectively investigated clinical factors important to achieve observation of the entire colon on CCE. The participants were 70 patients for whom CCE was scheduled, and from whom written informed consent regarding participation in this study was obtained. We selected patient background/examination factors, and analyzed all factors involved in observation of the entire colon and factors for completion of the CCE within 4 h after the start of examination using multivariate analysis. Of the 70 enrolled patients, 64 were analyzed, excluding 6. On multiple logistic analysis, only a water intake of ⩾12.0 ml/min during examination [p = 0.025, odds ratio (OR): 46.753, 95% confidence interval (CI): 1.630–1341.248] was identified as an independent predictive factor involved in observation of the entire colon. With respect to factors involved in the completion of CCE within 4 h, multiple logistic analysis showed that a body mass index (BMI) of ⩾25 (p = 0.039, OR: 13.723, 95% CI: 1.135–165.913), the absence of constipation (p = 0.030, OR: 13.988, 95% CI: 1.287–152.047), and a water intake of ⩾12.0 ml/min during examination (p = 0.004, OR: 12.028, 95% CI: 2.225–65.029) were independent predictive factors. Completion of a CCE was most closely related to water intake per hour. In addition to water intake, CCE-promoting factors included a high BMI and the absence of constipation.