Hippocampal - diencephalic - cingulate networks for memory and emotion: An anatomical guide.
Hippocampal - diencephalic - cingulate networks for memory and emotion: An anatomical guide.
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DOI：
10.1177/2398212817723443
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发表时间：
2017-08-04
影响因子：
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通讯作者：
Aggleton, John P
中科院分区：
文献类型：
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作者：
Bubb, Emma J;Kinnavane, Lisa;Aggleton, John P
这篇综述汇集了来自神经束追踪研究的最新知识，以更新和重新考虑Papez（1937）最初强调的边缘连接在情绪中的假定作用。这些连接将海马和海马旁区与乳状体、丘脑前核和扣带回联系起来，这些结构现在都与记忆功能密切相关。本综述的另一个目标是描述该网络中各种连接所采取的路线。对这些边缘连接的最初描述是，它们相互连接的通路形成了一个在海马体形成中开始和结束的串行电路。现在很清楚，除了乳腺外，这些不同的部位是相互联系的，包括许多相互联系。此外，这些相同的连接在地形上组织起来，创建了进一步的子系统。这种复杂的连通性模式有助于解释解释网络中任何单个位点受损的功能结果的困难。出于同样的原因，Papez最初关于回路开始和结束于海马体形成的概念需要被视为一个更复杂的海马体-间脑-扣带连接系统。这些多重相互作用的功能可能被更好地视为主要提供来自后内侧颞叶的传出信息。皮层下间脑通路（通过穹窿）和皮层扣带通路（通过脾后皮层）均可区分。这些途径为海马与前额叶皮层的相互作用提供了间接途径，这两组连接的优势来自更后方的海马区域。这些多阶段连接补充了海马到前额叶皮层的直接投射，这主要来自海马前部，从而在海马前后平面上产生纵向功能差异。
This review brings together current knowledge from tract tracing studies to update and reconsider those limbic connections initially highlighted by Papez (1937) for their presumed role in emotion. These connections link hippocampal and parahippocampal regions with the mammillary bodies, the anterior thalamic nuclei, and the cingulate gyrus, all structures now strongly implicated in memory functions. An additional goal of this review is to describe the routes taken by the various connections within this network. The original descriptions of these limbic connections saw their interconnecting pathways forming a serial circuit that began and finished in the hippocampal formation. It is now clear that, with the exception of the mammillary bodies, these various sites are multiply interconnected with each other, including many reciprocal connections. In addition, these same connections are topographically organised, creating further subsystems. This complex pattern of connectivity helps to explain the difficulty of interpreting the functional outcome of damage to any individual site within the network. For these same reasons, Papez' initial concept of a loop beginning and ending in the hippocampal formation needs to be seen as a much more complex system of hippocampal-diencephalic-cingulate connections. The functions of these multiple interactions might be better viewed as principally providing efferent information from the posterior medial temporal lobe. Both a subcortical diencephalic route (via the fornix) and a cortical cingulate route (via retrosplenial cortex) can be distinguished. These routes provide indirect pathways for hippocampal interactions with prefrontal cortex, with the preponderance of both sets of connections arising from the more posterior hippocampal regions. These multi-stage connections complement the direct hippocampal projections to prefrontal cortex, which principally arise from the anterior hippocampus, thereby creating longitudinal functional differences along the anterior-posterior plane of the hippocampus.