Expression of urokinase-type plasminogen activator system in prostate cancer: Correlation with clinicopathological outcomes in patients undergoing radical prostatectomy
Expression of urokinase-type plasminogen activator system in prostate cancer: Correlation with clinicopathological outcomes in patients undergoing radical prostatectomy
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DOI：
10.1016/j.urolonc.2008.01.012
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发表时间：
2009-03-01
影响因子：
2.7
通讯作者：
Fujisawa, Masato
中科院分区：
文献类型：
--
作者：
Kumano, Masafumi;Miyake, Hideaki;Fujisawa, Masato
本研究的目的是评估尿激酶型纤溶酶原激活物（uPA）系统在根治性前列腺癌切除术（RP）标本中的表达水平，以阐明uPA系统在前列腺癌中的意义。通过免疫组化染色评价了153例未接受任何新辅助治疗的临床器官局限性前列腺癌患者RP标本中uPA、uPA受体（uPAR）、纤溶酶原激活物抑制剂-1（派-1）和派-2的表达水平。在大多数前列腺癌标本中发现了不同水平的uPA、uPAR、派-1和派-2表达。uPA和uPAR的表达水平与肿瘤的病理分期、Gleason评分、淋巴结浸润、手术切缘状态和淋巴结转移等预后指标相关。而派-1的表达仅与病理分期和手术切缘状态有关，派-2的表达水平与所检测的几个参数之间无显著相关性。尽管派-2表达缺乏预后意义，但uPA、uPAR和派-1强表达患者的生化无复发生存率分别显著低于uPA、uPAR和派-1弱表达患者。此外，uPA的强表达，加上Gleason评分，阳性手术切缘，淋巴结转移可能是RP后生化复发的独立预测因子。提示uPA系统可能参与了前列腺癌的发生、发展过程，uPA在前列腺癌组织中的表达水平可作为RP患者生化复发的一个有用的预测指标。(C)2009 Elsevier Inc. All rights reserved.
The objective of this Study was to evaluate the expression levels of urokinase-type plasminogen activator (uPA) system in radical prostatectomy (RP) specimens in order to clarify the significance of the uPA system in prostate cancer. Expression levels of uPA, uPA receptor (uPAR), plasminogen activator inhibitor-1 (PAI-1), and PAI-2 in RP specimens obtained from 153 patients with clinically organ-confined prostate cancer who had not received any neoadjuvant therapies were evaluated by immunohistochemical staining. Various expression levels of uPA, uPAR, PAI-1, and PAI-2 were noted in the majority of prostate cancer specimens. Expression levels of uPA and uPAR were significantly associated with major prognostic indicators, including pathological stage, Gleason score, lymphatic invasion, surgical margin status and lymph node metastasis. However, PAI-1 expression was related to only pathological stage and surgical margin status, and there was no significant association between the expression level of PAI-2 and several parameters examined. Despite the lack of prognostic significance in PAI-2 expression, biochemical recurrence-free survival of patients with strong uPA, uPAR, and PAI-1 expression was significantly lower than that of those with weak uPA, uPAR, and PAI-1 expression, respectively. Furthermore, strong expression of uPA in addition to a Gleason score, positive surgical margin, and lymph node metastasis could be independent predictors for biochemical recurrence after RP. These findings Suggest that the uPA system may be involved in the progression of prostate cancer, and that the expression level of uPA in prostate cancer tissue Could be used as a useful predictor of biochemical recurrence in patients undergoing RP. (C) 2009 Elsevier Inc. All rights reserved.