Microglial ion channels: Key players in non-cell autonomous neurodegeneration.
Microglial ion channels: Key players in non-cell autonomous neurodegeneration.
复制标题
DOI：
10.1016/j.nbd.2022.105861
复制
发表时间：
2022-11
影响因子：
6.1
通讯作者：
Sarkar, Souvarish
中科院分区：
文献类型：
--
作者：
Sarkar, Souvarish
神经炎症是神经退行性疾病（包括阿尔茨海默病（AD）、帕金森病（PD）和创伤性脑损伤（TBI））的关键病理生理学标志。小胶质细胞是大脑的第一反应者，是这种神经炎症的驱动因素。小胶质细胞活化，导致诱导促炎因子，如白细胞介素1-β（IL-1β）、肿瘤坏死因子-α（TNFα）、亚硝酸盐等，已显示可诱导神经变性。非甾体抗炎药（NSAIDs）已被证明可以降低PD的风险，但小胶质细胞激活的机制仍在积极研究中。最近，小胶质细胞离子通道已成为多种神经退行性疾病（包括AD和PD）的潜在药物靶点。小胶质细胞表达多种离子通道，包括钾通道、钙通道、氯通道、钠通道和质子通道。存在于小胶质细胞上的通道的多样性负责这些大脑免疫细胞的动态性质。这些离子通道调节小胶质细胞增殖、趋化性、吞噬作用、抗原识别和呈递、细胞凋亡和导致炎症的细胞信号传导以及其他关键功能。了解这些离子通道的作用和这些通道在病理条件下调节的信号传导机制是一个活跃的研究领域。本文将重点介绍不同的小胶质细胞离子通道的作用，以及它们在神经退行性疾病中调节小胶质细胞功能的潜在作用。
Neuroinflammation is a critical pathophysiological hallmark of neurodegenerative disorders, including Alzheimer’s disease (AD), Parkinson’s disease (PD), and traumatic brain injury (TBI). Microglia, the first responders of the brain, are the drivers of this neuroinflammation. Microglial activation, leading to induction of pro-inflammatory factors, like Interleukin 1-β (IL-1β), Tumor necrosis factor-α (TNFα), nitrites, and others, have been shown to induce neurodegeneration. Non-steroidal anti-inflammatory drugs (NSAIDs) have been shown to reduce the risk of developing PD, but the mechanism underlying the microglial activation is still under active research. Recently, microglial ion channels have come to the forefront as potential drug targets in multiple neurodegenerative disorders, including AD and PD. Microglia expresses a variety of ion channels, including potassium channels, calcium channels, chloride channels, sodium channels, and proton channels. The diversity of channels present on microglia is responsible for the dynamic nature of these immune cells of the brain. These ion channels regulate microglial proliferation, chemotaxis, phagocytosis, antigen recognition and presentation, apoptosis, and cell signaling leading to inflammation, among other critical functions. Understanding the role of these ion channels and the signaling mechanism these channels regulate under pathological conditions is an active area of research. This review will be focusing on the roles of different microglial ion channels, and their potential role in regulating microglial functions in neurodegenerative disorders.
登录
查看更多内容
影响因子：
64.8
作者：
通讯作者：
--
影响因子：
5.3
作者：
Bouhy, Delphine;Ghasemlou, Nader;David, Samuel
通讯作者：
David, Samuel
右美沙芬抑制脂多糖诱导的原代大鼠小胶质细胞肿瘤坏死因子-α 表达的表观遗传组蛋白调节
影响因子：
4.6
作者：
Yang YN;Yang YC;Wu PL;Yang CH;Kuo KC;Yang SN
通讯作者：
Yang SN
影响因子：
5.5
作者：
Beck, Andreas;Penner, Reinhold;Fleig, Andrea
通讯作者：
Fleig, Andrea
影响因子：
6.3
作者：
Chen, Yi-Je;Raman, Girija;Wulff, Heike
通讯作者：
Wulff, Heike