Isoflurane-induced surgical tolerance mediated only in part by β3-containing GABAA receptors
Isoflurane-induced surgical tolerance mediated only in part by β3-containing GABAA receptors
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DOI：
10.1016/j.ejphar.2005.04.030
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发表时间：
2005-05-23
影响因子：
5
通讯作者：
Rudolph, U
中科院分区：
文献类型：
--
作者：
Lambert, S;Arras, M;Rudolph, U
介导挥发性全身麻醉剂异氟烷作用的靶点尚不清楚。基于使用GABA（A）受体拮抗剂的药理学研究，最近提出GABA（A）受体不会介导异氟烷的固定作用。使用β 3（N265M）基因敲入小鼠模型，我们发现突变小鼠对异氟烷的固定作用不太敏感，表明含β 3的GABA（A）受体在介导不动性中的作用。在高浓度下，异氟烷也使β 3（N265M）小鼠不动，表明其他靶点也介导不动性。因此，我们的研究结果支持异氟烷固定作用的多位点模型。(c)2005 Elsevier B.V.保留所有权利。
The targets which mediate the actions of the volatile general anaesthetic isoflurane are unknown. Based on pharmacological studies using GABA(A) receptor antagonists it has recently been suggested that GABA(A) receptors would not mediate the immobilizing action of isoflurane. Using the beta 3(N265M) knock-in mouse model we found that the mutant mice were less sensitive to the immobilizing action of isoflurane, indicating a role of beta 3-containing GABA(A) receptors in mediating immobility. At high concentrations isoflurane also immobilizes beta 3(N265M) mice, indicating that other targets also mediate immobility. Thus, our findings support a multisite model for the immobilizing action of isoflurane. (c) 2005 Elsevier B.V. All rights reserved.