Carbohydrates in chemistry and biology
Carbohydrates in chemistry and biology
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化学和生物学中的碳水化合物
DOI：
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发表时间：
2000
期刊：
影响因子：
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通讯作者：
P. Sinaÿ
中科院分区：
文献类型：
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作者：
B. Ernst;G. Hart;P. Sinaÿ
=摘要碳水化合物化学和糖生物学在过去几年中迅速发展，开发了许多新的、富有想象力和有效的合成方法，为糖缀合物的结构和生物相互作用提供了进一步的见解。糖基化反应广泛应用于药物和生物活性化合物的合成。在生物学和医学中，寡糖在免疫刺激、癌症或过敏反应中起着重要作用。糖科学是一个非常有启发性的例子，说明一个共同感兴趣的话题如何刺激化学和生物学共同开辟科学前沿。这种协同作用在这项工作中显而易见。糖化学和糖生物学领域的三位领先专家邀请了众多知名作者，全面概述了糖科学的最新进展和发现。这四卷本手册提出了一个综合的和前沿的观点，并涵盖了所有的化学方面，如碳水化合物和寡糖的合成和分析，以及寡糖的生物作用和活性以及碳水化合物/蛋白质相互作用。
= Abstract Carbohydrate Chemistry and Glycobiology have witnessed a rapid expansion during the last few years with the development of numerous new, imaginative and efficient syntheses which provide further insight into structures and biological interactions of glycoconjugates. Glycosylation reactions are widely used in the synthesis of pharmaceuticals and bio-active compounds. In biology and medicine oligosaccharides play a central role in immunostimulation, cancer or allergic responses. Glycoscience is a very instructive example of how one common topic of interest stimulates both chemistry and biology to collectively open scientific frontiers. This synergy is made visible in this work. Three leading experts in the fields of Glycochemistry and Glycobiology have invited numerous renowned authors to provide a comprehensive overview of the recent advances and findings in Glycoscience. This four-volume handbook presents an integrated and cutting-edge view, and covers all chemical aspects, such as syntheses and analysis of carbohydrates and oligosaccharides, as well as the biological role and activity of oligosaccharides and carbohydrate/protein interactions.