Current views on eye development
Current views on eye development
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DOI：
10.1016/s0166-2236(97)01082-5
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发表时间：
1997-09
影响因子：
15.9
通讯作者：
G. Oliver;P. Gruss
中科院分区：
文献类型：
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作者：
G. Oliver;P. Gruss
在不同物种中，已经确定了几个与眼睛发育调控有关的基因。在果蝇和老鼠等不同的生物体中，已经发现其中一些基因之间存在结构和功能上的保守。一个值得注意的例子是老鼠Pax6基因与果蝇眼睛之间的关系。果蝇体内老鼠Pax6基因的异位表达会导致额外眼睛的形成。最近，另一个同源框基因Six3被发现促进鱼胚胎异位晶状体的形成。下一步将是解开这些基因的相关调控途径，并评估它们表现出进化保守性的程度。这对于将这些发现与当前的解剖学和胚胎学模型进行同化具有重要意义。似乎有理由相信，在不久的将来，脊椎动物眼睛发育所需的整个框架的特征将完成。
Several genes involved in the regulation of eye development in different species have been identified. Structural and functional conservation have been found between some of these genes in organisms as diverse asDrosophilaand mouse. One notable example is the relationship between the mousePax6gene andeyelessofDrosophila.Ectopic expression ofeyelessor mousePax6inDrosophilaresults in the formation of additional eyes. Recently, another homeobox gene,Six3, was found to promote ectopic lens formation in fish embryos. The next step will be to unravel the associated regulatory pathways of these genes and assess the degree to which they display evolutionary conservation. This will be important in order to assimilate these findings with current anatomical and embryological models. It seems reasonable to believe that in the near future the characterization of the whole framework required for vertebrate eye development will be accomplished.