Ipsilateral utricular and semicircular canal interactions from electrical stimulation of individual vestibular nerve branches recorded in the descending medial longitudinal fasciculus
Ipsilateral utricular and semicircular canal interactions from electrical stimulation of individual vestibular nerve branches recorded in the descending medial longitudinal fasciculus
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下降内侧纵束中记录的单个前庭神经分支的电刺激引起的同侧椭圆囊和半规管相互作用
DOI：
10.1016/0006-8993(77)90357-2
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发表时间：
1977
期刊：
影响因子：
2.9
通讯作者：
C. Barnes
中科院分区：
文献类型：
--
作者：
Eunice J. Searles;C. Barnes
已在未麻醉的去大脑去小脑猫中研究了从内侧纵束 (MLF) 尾部突出的二阶前庭神经元记录的单个前庭终末器官神经电刺激的相互作用。使用各种条件测试参数记录管-管和椭圆囊-管相互作用。脑干被切片以消除对侧前庭核的影响，并重复条件测试实验。观察到的相互作用的类型（抑制或促进）及其发生的程度取决于 MLF 记录位点。此外，在椭圆囊相互作用的情况下，这些取决于椭圆囊刺激的部位。这些依赖性表明从受体细胞通过二阶神经元投射通路的拓扑排列。脑干的切片产生了相互作用模式的变化，表明同侧相互作用的掩蔽和/或平衡。在前管和后管之间的相互作用中，切片前没有发生明显相互作用的情况在切片后转变为抑制。这表明发生了一些促进相互作用，涉及来自对侧前庭核团的反馈，并且这种促进掩盖或平衡了同侧抑制。在前管和水平管之间的相互作用中，对侧抑制性影响掩盖了同侧促进性相互作用。对侧促进影响再次平衡水平和后神经管之间相互作用的同侧抑制。观察到的抑制和促进程度表明，二阶前庭神经元上发生的多突触同侧汇聚比细胞内研究中所证实的要多得多。当切片后通过刺激椭圆囊神经调节前管时，仅观察到抑制。在所有其他配对中，观察到混合效应。这表明这与半规管二级神经元与颈部运动神经元的已知功能连接有关。不仅运河输出受到椭圆囊活动的影响，而且每条运河以不同的方式影响椭圆囊输出。
Interactions from electrical stimulation of individual vestibular end organ nerves recorded from second order vestibular neurons projecting caudally in the medial longitudinal fascinulus (MLF) have been investigated in unanesthetized, decerebrate decerebellate cats. Canal-canal and utricle-canal interactions were recorded using various condition-test parameters. The brain stem was sectioned to eliminate influence of the contralateral vestibular nuclei, and the condition-test experiments were repeated.The type of interaction observed (inhibition or facilitation) and the degree to which it occurred were dependent on the MLF recording site. Also, in the case of utricular interactions, these were dependent on the site of utricular stimulation. These dependencies indicate a topological arrangement from receptor cell through the second order neuronal projection pathways.Sectioning of the brain stem produced changes in the interaction patterns, indicating masking and/or balancing of the ipsilateral interactions. In interactions between the anterior and posterior canals, instances of no apparent interactions occuring before sectioning converted to inhibition after sectioning. This indicates that some facilitative interaction occurs involving feedback from the contralateral vestibular nuclei, and this facilitation masks or balances ipsilateral inhibition. In interactions between the anterior and horizontal canals, contralateral inhibitory influence masks ipsilateral facilitatory interactions. Contralateral facilitatory influence again balances ipsilateral inhibition in interactions between the horizontal and posterior canals. The degree of inhibition and facilitation observed indicates that considerably more polysynaptic ipsilateral convergence on second order vestibular neurons occurs than has been demonstrated in intracellular studies.Only inhibition was observed when the anterior canal was conditioned by stimulation of the utricular nerve after sectioning. In all other pairings, mixed effects were observed. It is suggested that this is related to known functional connections of semicircular canal second order neurons with neck motoneurons. Not only is canal output affected by utricular activity, but each canal affects utricular output in a different manner.