Targeting Proinflammatory Molecules Using Multifunctional MnO Nanoparticles to Inhibit Breast Cancer Recurrence and Metastasis.
Targeting Proinflammatory Molecules Using Multifunctional MnO Nanoparticles to Inhibit Breast Cancer Recurrence and Metastasis.
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DOI：
10.1021/acsnano.2c06713
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发表时间：
2022-11
期刊：
影响因子：
17.1
通讯作者：
Yiling Zhong;Tianyu Li;Yuefei Zhu;Jiehau Zhou;Tolulope Akinade;Jounghyun H Lee;Feng Liu;Divya Bhansali;Yeh-Hsing Lao;C. Quek;Dan Shao;Kam W. Leong
中科院分区：
文献类型：
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作者：
Yiling Zhong;Tianyu Li;Yuefei Zhu;Jiehau Zhou;Tolulope Akinade;Jounghyun H Lee;Feng Liu;Divya Bhansali;Yeh-Hsing Lao;C. Quek;Dan Shao;Kam W. Leong
光热治疗(PTT)是一种有效的治疗方式，对肿瘤的抑制具有高度的选择性，是传统癌症治疗的一种有希望的替代方案。然而，PTT诱导的炎症反应可能会导致不良的副作用，包括增加肿瘤复发和转移的风险。在这里，我们开发了多功能的MnO纳米颗粒，作为促炎分子的清除剂，以减轻PTT诱导的炎症反应。纳米MnO通过(1)结合和清除促炎分子以抑制促炎分子诱导的Toll样受体(TLR)激活和核因子-kappaB(NF-κB)信号转导；(2)抑制激活的巨噬细胞诱导的巨噬细胞募集；(3)抑制肿瘤细胞的迁移和侵袭，从而改善PTT治疗。体内实验结果表明，激光治疗后进一步应用纳米MnO不仅抑制了PTT诱导的炎症反应和原发肿瘤复发，而且由于其清除肿瘤的活性，显着减少了肿瘤的转移。这些发现表明，MnO纳米颗粒具有减轻治疗引起的严重炎症反应和抑制肿瘤复发和转移的潜力。
Photothermal therapy (PTT) is an effective treatment modality that is highly selective for tumor suppression and is a hopeful alternative to traditional cancer therapy. However, PTT-induced inflammatory responses may result in undesirable side effects including increased risks of tumor recurrence and metastasis. Here we developed multifunctional MnO nanoparticles as scavengers of proinflammatory molecules to alleviate the PTT-induced inflammatory response. The MnO nanoparticles improve the PTT therapy by (1) binding and scavenging proinflammatory molecules to inhibit the proinflammatory molecule-induced Toll-like receptors (TLR) activation and nuclear factor kappa B (NF-κB) signaling; (2) inhibiting activated macrophage-induced macrophage recruitment; and (3) inhibiting tumor cell migration and invasion. In vivo experimental results showed that further treatment with MnO nanoparticles after laser therapy not only inhibited the PTT-induced inflammatory response and primary tumor recurrence but also significantly reduced tumor metastasis due to the scavenging activity. These findings suggest that MnO nanoparticles hold the potential for mitigating the therapy-induced severe inflammatory response and inhibiting tumor recurrence and metastasis.