Iron oxide nanoclusters for T1 magnetic resonance imaging of non-human primates
Iron oxide nanoclusters for T1 magnetic resonance imaging of non-human primates
复制标题
用于非人类灵长类动物 T1 磁共振成像的氧化铁纳米团簇
DOI：
10.1038/s41551-017-0116-7
复制
发表时间：
2017-08-01
影响因子：
28.1
通讯作者：
Zou, Duo-Hong
中科院分区：
文献类型：
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作者：
Lu, Yang;Xu, Yun-Jun;Zou, Duo-Hong
用于磁共振成像（MRI）的氧化铁造影剂已在美国和欧洲获得临床批准，但大多数纳米颗粒产品由于无法满足严格的临床要求而被停产。磁性纳米颗粒的合成及其生物医学应用已经取得了重大进展，但其临床转化仍面临几个主要挑战，特别是大规模和可重复的合成，系统毒性评估以及大型动物MRI的临床前评估。在这里，我们报告了在大型动物模型（包括比格犬和临床相关的猕猴）中对均匀大小的氧化铁纳米团簇的毒性研究结果。我们还表明，氧化铁纳米团簇可以用作T1 MRI造影剂，用于比格犬和猕猴的高分辨率磁共振血管造影，并且动态MRI可以检测这些大型动物的脑缺血。氧化铁纳米团簇显示出作为下一代MRI造影剂的临床潜力。均匀的氧化铁纳米颗粒簇具有高度的生物相容性，可以用作大型动物高分辨率磁共振血管造影的造影剂。
Iron-oxide-based contrast agents for magnetic resonance imaging (MRI) had been clinically approved in the United States and Europe, yet most of these nanoparticle products were discontinued owing to failures to meet rigorous clinical requirements. Significant advances have been made in the synthesis of magnetic nanoparticles and their biomedical applications, but several major challenges remain for their clinical translation, in particular large-scale and reproducible synthesis, systematic toxicity assessment, and their preclinical evaluation in MRI of large animals. Here, we report the results of a toxicity study of iron oxide nanoclusters of uniform size in large animal models, including beagle dogs and the more clinically relevant macaques. We also show that iron oxide nanoclusters can be used as T1 MRI contrast agents for high-resolution magnetic resonance angiography in beagle dogs and macaques, and that dynamic MRI enables the detection of cerebral ischaemia in these large animals. Iron oxide nanoclusters show clinical potential as next-generation MRI contrast agents. Uniform iron oxide nanoparticle clusters are highly biocompatible and can be used as contrast agents for high-resolution magnetic resonance angiography of large animals.