Rates of Neuroretinal Rim and Peripapillary Atrophy Area Change A Comparative Study of Glaucoma Patients and Normal Controls
Rates of Neuroretinal Rim and Peripapillary Atrophy Area Change A Comparative Study of Glaucoma Patients and Normal Controls
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DOI：
10.1016/j.ophtha.2008.12.005
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发表时间：
2009-05-01
期刊：
影响因子：
13.7
通讯作者：
Chauhan, Balwantray C.
中科院分区：
文献类型：
--
作者：
See, Jovina L. S.;Nicolela, Marcelo T.;Chauhan, Balwantray C.
目的：比较开角型青光眼患者和正常对照组整体和局部神经视网膜边缘面积(NRA)和乳头周围萎缩面积(PPAA)的变化率，并确定NRA和PPAA变化率之间的关系。设计：前瞻性纵向队列研究病例和对照组：94例开角型青光眼患者和54例对照组。方法：每6个月对患者和对照组进行激光共聚焦扫描断层扫描。对1只眼的NRA和PPAA进行分析，通过回归分析确定全球和12个30个行业的变化率。全球NRA和PPAA变化率呈正相关。根据NRA和PPAA变化的大小，每个部门从1到12排名，并使用等级顺序相关性在患者和对照组之间进行比较。结果：患者的平均(+/-)标准差为8.6+/-2.9年，对照组为7.1+/-3.6年。总体而言，与对照组相比，患者的NRA下降更快，以绝对单位(中位数分别为-5.33x10(-3)mm(2)/年和-1.25x10(-3)mm~2/年；P=0.006)或基线NRA的百分比(中位数分别为-0.42%/年和-0.07%/年；P=0.001)表示。PPAA总变化率分别为12.66×10~(-3)mm~2/年和9.43×10~(-3)mm~2/年，与对照组比较差异无统计学意义(P=0.173)。全球和行业的NRA和PPAA变化率在任何一组中相关性都很差。患者组和对照组的NRA变化分级指标之间存在高度相关性(P
Objective: To compare the rates of global and sectoral neuroretinal rim area (NRA) and peripapillary atrophy area (PPAA) change in open-angle glaucoma patients and normal control subjects and to determine the relationship between rates of NRA and PPAA change.Design: Prospective, longitudinal cohort study of cases and controls.Participants and Controls: Ninety-four patients with open-angle glaucoma and 54 control subjects.Methods: Patients and controls were imaged with confocal scanning laser tomography every 6 months. The NRA and PPAA in 1 eye were analyzed to determine the rate of change globally and in 12 30 sectors by regression analysis. Rates of global NRA and PPAA change were correlated. Sectors were ranked from 1 to 12 each according to the magnitude of NRA and PPAA change and were compared between patients and controls using rank-order correlation. Spatial concordance between rates of NRA and PPAA change was calculated as sector rank distance between correspondingly ranked sectors.Main Outcome Measures: Rates of global and sectoral NRA and PPAA change.Results: The mean (+/- standard deviation) follow-up was 8.6 +/- 2.9 years for patients and 7.1 +/- 3.6 years for controls. Globally, NRA declined more rapidly in patients compared with controls, expressed either in absolute units (medians, -5.33 x 10(-3) mm(2)/year and -1.25 x 10(-3) mm2/year, respectively; P = 0.006) or percentage of baseline NRA (medians, -0.42%/year and -0.07%/year, respectively; P = 0.001). The global rate of PPAA change was not significantly higher in patients compared with controls (12.66 x 10(-3) mm2/year and 9.43 x 10(-3) mm2/year, respectively; P = 0.173). Rates of global and sectoral NRA and PPAA change were correlated poorly in either group. There was a high correlation between ranked sectors of NRA change in patients and controls (P