Local Gyrification Index in Patients with Major Depressive Disorder and its Association with Tryptophan Hydroxylase-2 (TPH2) Polymorphism
Local Gyrification Index in Patients with Major Depressive Disorder and its Association with Tryptophan Hydroxylase-2 (TPH2) Polymorphism
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DOI：
10.1002/hbm.23455
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发表时间：
2017-03-01
影响因子：
4.8
通讯作者：
Ham, Byung-Joo
中科院分区：
文献类型：
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作者：
Han, Kyu-Man;Won, Eunsoo;Ham, Byung-Joo
色氨酸羟化酶-2 （TPH2）基因被认为是一个有希望的遗传候选基因，因为它与重度抑郁症（MDD）的易感性有关。局部回旋反映了皮层连通性的早期神经发育，被认为是精神疾病中一种潜在的神经内表型。他们的目的是研究重度抑郁症患者前额叶皮层和前扣带皮层皮质回化的改变及其与TPH2 rs4570625多态性的关系。113例重度抑郁症患者和86例健康对照接受了t1加权结构磁共振成像和TPH2 rs4570625基因分型。用FreeSurfer分析了前额皮质和前扣带皮质22个皮质区域的局部回转指数。MDD患者在右侧扣带前皮层吻侧（P50.001）、眶额皮质内侧（P50.003）和额极（P50.001）均表现出明显的脑回功能亢进。右侧吻侧前扣带皮层局部旋回指数存在显著的基因型诊断交互作用（P50.003）。他们的研究揭示了显著的前扣带皮层和前额皮质的脑回功能亢进，以及MDD的诊断与前扣带皮层基因型之间的相互作用。这可能与调节情绪处理的神经回路功能障碍有关，这可能有助于MDD的病理生理。(C) 2016 Wiley期刊公司
The tryptophan hydroxylase-2 (TPH2) gene is considered a promising genetic candidate regarding its association with a predisposition to major depressive disorder (MDD). Local gyrification reflects the early neural development of cortical connectivity, and is regarded as a potential neural endophenotype in psychiatric disorders. They aimed to investigate the alterations in the cortical gyrification of the prefrontal cortex and anterior cingulate cortex and their association with the TPH2 rs4570625 polymorphism in patients with MDD. One hundred and thirteen patients with MDD and eighty-six healthy controls underwent T1-weighted structural magnetic resonance imaging and genotyping for TPH2 rs4570625. The local gyrification index of 22 cortical regions in the prefrontal cortex and anterior cingulate cortex was analyzed using the FreeSurfer. The patients with MDD showed significant hypergyria in the right rostral anterior cingulate cortex (P50.001), medial orbitofrontal cortex (P50.003), and frontal pole (P50.001). There was a significant genotype-by-diagnosis interaction for the local gyrification index in the right rostral anterior cingulate cortex (P50.003). Their study revealed significant hypergyria of the anterior cingulate cortex and prefrontal cortex and an interactive effect between the diagnosis of MDD and the genotype in the anterior cingulate cortex. This might be associated with the dysfunction of neural circuits mediating emotion processing, which could contribute to pathophysiology of MDD. (C) 2016 Wiley Periodicals, Inc.