Single Synapse Information Coding in Intraburst Spike Patterns of Central Pattern Generator Motor Neurons
Single Synapse Information Coding in Intraburst Spike Patterns of Central Pattern Generator Motor Neurons
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DOI：
10.1523/jneurosci.1568-11.2011
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发表时间：
2011-08-24
影响因子：
5.3
通讯作者：
Pinto, Reynaldo D.
中科院分区：
文献类型：
--
作者：
Brochini, Ludmila;Carelli, Pedro V.;Pinto, Reynaldo D.
爆发性放电在神经系统中普遍存在，并且在中枢模式发生器（CPG）中得到了深入研究。以前的工作已经描述了微妙的爆发内尖峰模式（IBSP），尽管传统上被忽视的CPG运动功能的关系缺乏，被证明是细胞类型特异性和敏感的CPG连接。在这里，我们解决这个问题，通过研究如何爆发运动神经元表达有关网络中其他神经元的信息。我们进行实验的甲壳类动物口胃幽门CPG，无论是在控制条件下，并在实时与计算机模型神经元的相互作用。通过计算沿沿着每个神经元爆发的平均互信息来推断突触后IBSP对突触前IBSP的敏感性。我们发现，输入模式的细节通过单个突触非线性且不均匀地编码到爆发后突触后神经元的精细IBSP结构中。通过这种方式，运动神经元能够使用不同的时间尺度同时传达两种类型的信息：肌肉收缩（与爆发节律相关）和其他CPG神经元的行为（通过使用IBSP作为信息载体，在更短的时间尺度上）。此外，分析表明，编码机制描述的一部分，在以前未知的信息通路从CPG运动神经元的神经，项目的感觉脑区，从而提供证据的一般生理作用的信息编码通过IBSP在调节神经元放电模式在远程电路的中枢神经系统。
Burst firing is ubiquitous in nervous systems and has been intensively studied in central pattern generators (CPGs). Previous works have described subtle intraburst spike patterns (IBSPs) that, despite being traditionally neglected for their lack of relation to CPG motor function, were shown to be cell-type specific and sensitive to CPG connectivity. Here we address this matter by investigating how a bursting motor neuron expresses information about other neurons in the network. We performed experiments on the crustacean stomatogastric pyloric CPG, both in control conditions and interacting in real-time with computer model neurons. The sensitivity of postsynaptic to presynaptic IBSPs was inferred by computing their average mutual information along each neuron burst. We found that details of input patterns are nonlinearly and inhomogeneously coded through a single synapse into the fine IBSPs structure of the postsynaptic neuron following burst. In this way, motor neurons are able to use different time scales to convey two types of information simultaneously: muscle contraction (related to bursting rhythm) and the behavior of other CPG neurons (at a much shorter timescale by using IBSPs as information carriers). Moreover, the analysis revealed that the coding mechanism described takes part in a previously unsuspected information pathway from a CPG motor neuron to a nerve that projects to sensory brain areas, thus providing evidence of the general physiological role of information coding through IBSPs in the regulation of neuronal firing patterns in remote circuits by the CNS.