Establishment of TBS reference plots and correlation between TBS and BMD in healthy mainland Chinese women
Establishment of TBS reference plots and correlation between TBS and BMD in healthy mainland Chinese women
复制标题
中国大陆健康女性TBS参考图的建立及TBS与BMD的相关性
DOI：
10.1007/s11657-015-0254-z
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发表时间：
2016-12-01
影响因子：
3
通讯作者：
Ding, G. X.
中科院分区：
文献类型：
--
作者：
Cheng, P.;Qi, H. M.;Ding, G. X.
摘要通过双x线吸收仪（DXA）图像的灰度值获得骨小梁评分（TBS），以评价骨微结构。在此，我们建立了南京地区中国健康女性TBS的参考图。TBS参考值与法国和美国白人女性相似，但高于日本女性。目的建立南京地区中国健康女性TBS发病参考区。方法经南京医科大学第一附属医院伦理委员会批准，招募南京地区健康女性537例。采用双x线骨密度仪测定腰椎TBS和腰椎、股骨骨密度。计算不同年龄组妇女TBS的均数±标准差（SD）。采用回归分析计算TBS与年龄、骨密度的相关性。结果在南京地区20 ~ 89岁的健康女性中建立了TBS的参考图。全体受试者的TBS平均值为1.32±0.11，在20 ~ 29岁达到高峰，随后随年龄增长而下降。TBS与年龄的决定系数为0.5065，与BMD的决定系数为0.5191。调整腰椎总骨密度后，TBS与所有受试者的年龄显著相关，仅在50-59岁亚组中存在。结论TBS随年龄增长而降低，与BMD呈正相关。中国女性的TBS参考值与法国和美国白人女性相似，但高于日本女性。此外，TBS可能更显着应用于绝经期不足10年的妇女。
SummaryThe trabecular bone score (TBS) was obtained from the gray levels of a dual X-ray absorptiometry (DXA) image to evaluate bone microarchitecture. Here, we established the reference plots of TBS in healthy Chinese women of Nanjing area. The TBS references are similar with French and US Caucasian women but higher than Japanese women.PurposeThe aim of the study was to establish the reference plots of the TBS in healthy Chinese women of the Nanjing area.MethodsA total of 537 healthy Chinese women of the Nanjing area were recruited, and the study was approved by the Ethics Committee of the First Affiliated Hospital with Nanjing Medical University. The TBS of the lumbar spine and the bone mineral density (BMD) of the lumbar spine and femur were measured using dual X-ray absorptiometry. The mean ± standard deviation (SD) of the TBS in women with different age groups was calculated. The correlation of TBS and age and BMD was calculated using regression analysis.ResultsThe reference plots of the TBS were established in healthy Chinese women of the Nanjing area between the ages of 20 and 89 years. The average TBS for total subjects was 1.32 ± 0.11 and reached the peak at the age of 20–29 years and then decreased with age thereafter. The determinant coefficient between TBS and age was 0.5065 while between TBS and BMD was 0.5191. After adjusting for lumbar total BMD, the TBS significantly correlated with age in whole subjects and only in the subgroup of ages 50–59 years.ConclusionsThis study suggested that TBS decreased with age and correlated positively with BMD. The TBS reference of Chinese women is similar with those of French and US Caucasian women but higher than that of Japanese women. Furthermore, the TBS may be more significantly applied in women in menopause for less than 10 years.