Increased left ventricular mass and hypertrophy are associated with increased risk for sudden death
Increased left ventricular mass and hypertrophy are associated with increased risk for sudden death
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DOI：
10.1016/s0735-1097(98)00407-0
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发表时间：
1998-11-01
影响因子：
24
通讯作者：
Levy, D
中科院分区：
文献类型：
--
作者：
Haider, AW;Larson, MG;Levy, D
目标.本研究探讨了超声心动图测定的左心室（LV）质量和肥大与猝死风险的关系。超声心动图左心室肥大与全因死亡率和心血管疾病发病率和死亡率的风险增加相关。然而，关于超声心动图左室肥厚与猝死的关系知之甚少。我们在3,661名40岁以上的心脏病患者中研究了左心室质量和肥厚与猝死发生率的关系。基线检查在1979年至1983年进行，LV肥大定义为LV质量（根据身高调整）男性> 143 g/m，女性> 102 g/m。在长达14年的随访中，有60例猝死。考克斯模型在校正已知的危险因素后检测了左心室质量和左心室肥大与猝死风险的关系。左室肥厚的患病率为21.5%。左心室质量每增加50 g/m，猝死的风险因素校正风险比（HR）为1.45（95%置信区间[CI] 1.10 - 1.92，p = 0.008）。对于LV肥大，猝死的危险因素校正IIR为2.16（95%CI 1.22至3.81，p = 0.008），排除第一个1年随访后，左心室质量增加和左心室肥大均具有猝死的长期风险（HR 1.53，95% CI 1.01至2.28，p = 0.047和IIR 3.28，95% CI 1.58至6.83，p = 0.002）。在考虑已知的危险因素后，左心室质量增加和肥大与猝死风险增加相关。(C)1998年，美国心脏病学会。
Objectives. This study examined the relations of echocardiographically graphically determined left ventricular (LV) mass and hypertrophy to the risk of sudden death.Background. Echocardiographic LV hypertrophy is associated with increased risk for all-cause mortality and cardiovascular disease morbidity and mortality. However, little is known about the association of echocardiographic LV hypertrophy with sudden death.Methods. We examined the relations of LV mass and hypertrophy to the incidence of sudden death in 3,661 subjects enrolled in the Framingham Heart Study who were greater than or equal to 40 years of age. The baseline examination was performed from 1979 to 1983 and LV hypertrophy was defined as LV mass (adjusted for height) > 143 g/m in men and > 102 g/m in women. During up to 14 years of follow-up there were 60 sudden deaths. Cox models examined the relations of LV mass and LV hypertrophy to sudden death risk after adjusting for known risk factors.Results. The prevalence of LV hypertrophy was 21.5%. The risk factor-adjusted hazard ratio (HR) for sudden death was 1.45 (95% confidence interval [CI] 1.10 to 1.92, p = 0.008) for each 50-g/m increment in LV mass. For LV hypertrophy, the risk factor-adjusted IIR for sudden death was 2.16 (95% CI 1.22 to 3.81, p = 0.008), After excluding the first I years of follow-up, both increased LV mass and LV hypertrophy conferred long-term risk of sudden death (HR 1.53, 95% CI 1.01 to 2.28, p = 0.047 and IIR 3.28, 95% CI 1.58 to 6.83, p = 0.002, respectively).Conclusions. Increased LV mass and hypertrophy are associated with increased risk for sudden death after accounting for known risk factors. (C) 1998 by the American College of Cardiology.