STUDIES ON THE ROLE OF FELINE CALICIVIRUS IN CHRONIC STOMATITIS IN CATS
STUDIES ON THE ROLE OF FELINE CALICIVIRUS IN CHRONIC STOMATITIS IN CATS
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DOI：
10.1016/0378-1135(91)90148-9
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发表时间：
1991-05-01
影响因子：
3.3
通讯作者：
GASKELL, RM
中科院分区：
文献类型：
--
作者：
KNOWLES, JO;MCARDLE, F;GASKELL, RM
两组猫经口-鼻接种从慢性口腔炎临床病例中分离的两株猫杯状病毒（FCV）之一。所有猫均出现急性FCV感染的典型体征;即眼和鼻分泌物、结膜炎和明显的口腔溃疡。没有一只猫在28天后脱落病毒。然后用较低剂量的一种分离株感染血清阴性对照猫，但同样仅观察到急性体征，未产生携带者。然后用异源分离株再次感染原始猫。如前所述，仅观察到急性疾病的体征，但临床体征和严重程度的范围缩小。一组的病毒脱落模式与最初观察到的相似，但另一组的持续时间缩短。在10个月的研究中没有发生慢性口腔炎。研究了血清病毒中和以及血清和唾液类特异性免疫球蛋白应答。尽管未诱导长期携带者，但未观察到个体动物中病毒脱落停止与全身和局部抗体应答之间的关系。
Two groups of cats were inoculated oro-nasally with one of two isolates of feline calicivirus (FCV) from clinical cases of chronic stomatitis. All cats developed signs typical of acute FCV infection; namely, ocular and nasal discharge, conjunctivitis, and marked oral ulceration. None of the cats shed virus beyond 28 days. Seronegative control cats were then infected with a lower dose of one isolate, but again only acute signs were seen and no carriers produced. The original cats were then re-infected with the heterologous isolate. As before, only signs of acute disease were seen, but the range of clinical signs and severity was reduced. Virus shedding patterns in one group were similar to those seen originally, but in the other the duration was reduced. No chronic stomatitis developed over the 10 months of the study. Serum virus neutralising and serum and salivary class specific immunoglobulin responses were investigated. Although long-term carriers were not induced, no relationship between cessation of virus shedding in an individual animal and systemic and local antibody responses was seen.