Corticatic acids D and E, polyacetylenic geranylgeranyltransferase type I inhibitors, from the marine sponge Petrosia corticata
Corticatic acids D and E, polyacetylenic geranylgeranyltransferase type I inhibitors, from the marine sponge Petrosia corticata
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DOI：
10.1021/np020080f
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发表时间：
2002-09-01
影响因子：
5.1
通讯作者：
Fusetani, N
中科院分区：
文献类型：
--
作者：
Nishimura, S;Matsunaga, S;Fusetani, N
从海绵Petrosia corticata沿着分离到两种新的聚炔酸，即皮质酸D（2）和E（3），以及已知的皮质酸A（1），它们都是香叶基香叶基转移酶I（GGT酶I）的抑制剂。根据光谱和化学方法鉴定了它们的结构。化合物1-3抑制白色念珠菌的GGT酶I，IC 50值为1.9-7.3 μ M。
Two new polyacetylenic acids, corticatic acids D (2) and E (3), have been isolated from the marine sponge Petrosia corticata along with the known corticatic acid A (1) as geranylgeranyltransferase type I (GGTase I) inhibitors. Their structures were elucidated on the basis of spectroscopic and chemical methods. Compounds 1-3 inhibited GGTase I from Candida albicans with IC50 values of 1.9-7.3 muM.