Effects of caffeine on learning and memory in rats tested in the Morris water maze
Effects of caffeine on learning and memory in rats tested in the Morris water maze
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DOI：
10.1590/s0100-879x2002001000013
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发表时间：
2002-10-01
影响因子：
2.3
通讯作者：
Cunha, C. Da
中科院分区：
文献类型：
--
作者：
Angelucci, M.E.M.;Cesário, C.;Cunha, C. Da
我们研究了非特异性腺苷受体拮抗剂，咖啡因，使用动物模型的学习和记忆的改善效果的一些特点。由12只成年雄性Wistar大鼠组成的组在训练前30分钟、训练后立即或测试前30分钟接受咖啡因（0.3-30 mg/kg，ip，0.1 ml/100 g体重），在空间版本中进行测试莫里斯水迷宫任务。训练后给予0.3-10 mg/kg剂量的咖啡因可改善记忆保持（在测试阶段中，大鼠找到平台的游泳距离减少了600 cm，P小于或等于0.05），但30 mg/kg剂量的咖啡因不能改善记忆保持。试验前给予咖啡因也引起记忆提取的小幅增加（大鼠的逃避路径缩短达500 cm，P小于或等于0.05）。相比之下，训练前给予咖啡因并没有改变动物在训练或测试阶段的表现。这些数据提供的证据表明，咖啡因可以改善记忆力的保持，但不能改善记忆力的获得，这解释了文献中报道的一些差异。
We studied some of the characteristics of the improving effect of the non-specific adenosine receptor antagonist, caffeine, using an animal model of learning and memory. Groups of 12 adult male Wistar rats receiving caffeine (0.3-30 mg/kg, ip, in 0.1 ml/100 g body weight) administered 30 min before training, immediately after training, or 30 min before the test session were tested in the spatial version of the Morris water maze task. Post-training administration of caffeine improved memory retention at the doses of 0.3-10 mg/kg (the rats swam up to 600 cm less to find the platform in the test session, Pless than or equal to0.05) but not at the dose of 30 mg/kg. Pre-test caffeine administration also caused a small increase in memory retrieval (the escape path of the rats was up to 500 cm shorter, Pless than or equal to0.05). In contrast, pre-training caffeine administration did not alter the performance of the animals either in the training or in the test session. These data provide evidence that caffeine improves memory retention but not memory acquisition, explaining some discrepancies among reports in the literature.