Development of the sensory nervous system in the vertebrate head: the importance of being on time.
Development of the sensory nervous system in the vertebrate head: the importance of being on time.
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DOI：
10.1016/j.gde.2012.05.003
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发表时间：
2012-08
影响因子：
4
通讯作者：
L. Lleras-Forero;A. Streit
中科院分区：
文献类型：
--
作者：
L. Lleras-Forero;A. Streit
感觉器官和颅感觉神经节在功能上是不同的，但有一个共同的发育起源。它们起源于一群多能祖细胞，局部信号逐渐限制它们的发育潜力，以指定内耳、嗅上皮、透镜和感觉神经元。这一过程需要多个信号通路的时间整合，交叉抑制转录因子的相互作用和细胞命运规范和形态发生的紧密协调。
Sense organs and cranial sensory ganglia are functionally diverse, yet share a common developmental origin. They arise from a pool of multipotent progenitors and local signals gradually restrict their development potential to specify the inner ear, olfactory epithelium, lens and sensory neurons. This process requires the temporal integration of multiple signalling pathways, cross-repressive transcription factor interactions and tight coordination of cell fate specification and morphogenesis.