Anisotropy of the elastic modulus of trabecular bone specimens from different anatomical locations
Anisotropy of the elastic modulus of trabecular bone specimens from different anatomical locations
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DOI：
10.1016/s1350-4533(98)00001-0
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发表时间：
1998-03-01
影响因子：
2.2
通讯作者：
Genant, HK
中科院分区：
文献类型：
--
作者：
Augat, P;Link, T;Genant, HK
为了将骨小梁的力学各向异性与骨密度(BMD)和力学性能之间的关系联系起来，对97个立方体人体松质骨标本进行了CT扫描。取脊柱、跟骨、股骨远端和股骨近端的骨块进行多方向静息，测量其压缩刚度并计算其力学各向异性比率，在头尾(c-c)方向进行破坏试验以确定极限强度。在c-c方向上，脊柱标本的压缩刚度最大，股骨远端和近端也是如此，但跟骨不是。股骨远端和脊柱c-e方向的各向异性比股骨近端大。BMD对力学性能的预测能力因解剖位置不同而不同，并强烈依赖于加载方向。而在脊柱，c-c硬度与BMD高度相关(r(2)=0.73)，垂直方向仅显示中等程度的相关性(r(2)<；0.53)，力学性能与BMD的相关性在各向异性不明显的位置(股骨近端)或比较均匀的位置(脊柱)最大。这些数据表明，骨密度可以最成功地应用于确定主要载荷方向的机械性能，从临床角度来看，这可能是最相关的。(C)1998年IPEM。爱思唯尔科学有限公司出版。版权所有。
To associate the mechanical anisotropy of trabecular bone with the relationship between bone mineral density (BMD) and mechanical properties, 97 cubic specimens of human trabecular bone were imaged with computed tomography. Bone cubes from the spine, the calcaneus, the distal, and the proximal femur were rested multidirectionally to measure their compressive stiffness and to calculate their ratios of mechanical anisotropy, The ultimate strength was determined in a destructive test in cephalo-caudal (c-c) direction. Compressive stiffness was largest in the c-c direction for the specimens from the spine, as well as the distal and the proximal femur, but not the calcaneus. Anisotropy ratios in c-e direction were larger at the distal femur and the spine than in the proximal femur. The predictive power of BMD for the mechanical properties varied with anatomical location and strongly depended on the loading direction. While at the spine the c-c stiffness was highly correlated to BMD (r(2) = 0.73), the perpendicular directions showed only modest correlations (r(2) < 0.53), The correlations of mechanical properties with BMD were greatest at locations where the anisotropy was less pronounced (proximal femur) or rather uniform (spine). The data suggest that BMD can be most successfully applied to determine the mechanical properties in the principal loading direction, which from a clinical perspective may be most relevant. (C) 1998 IPEM. Published by Elsevier Science Ltd. All rights reserved.