Extending the scope of a known furan synthesis: a novel route to 1,2,4-trisubstituted pyrroles
Extending the scope of a known furan synthesis: a novel route to 1,2,4-trisubstituted pyrroles
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扩展已知呋喃合成的范围：1,2,4-三取代吡咯的新路线
作者：
M. Friedrich;A. Wächtler;A. Meijere
2-（酰基亚甲基）丙二醇二乙酸酯在酸性条件下容易环化得到呋喃（76-84%），在钯催化下与伯胺反应得到1，2，4-三取代的吡咯，产率中等至良好（39-53%）。当甘氨酸甲酯用作胺时，得到取代的吡咯-1-基乙酸甲酯（31-82%）。
2-(Acylmethylene)propanediol diacetates, which cyclize readily under acidic conditions to give furans (76-84%) react with primary amines under palladium catalysis to give 1,2,4-trisubstituted pyrroles in moderate to good yields (39-53%). When glycine methyl ester is used as the amine, substituted methyl pyrrol-1-ylacetates (31-82%) are obtained.