Histories of substance use and risk behavior: Precursors to HIV seroconversion in homosexual men
Histories of substance use and risk behavior: Precursors to HIV seroconversion in homosexual men
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DOI：
10.2105/ajph.88.1.113
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发表时间：
1998-01-01
影响因子：
12.7
通讯作者：
Stall, R
中科院分区：
文献类型：
--
作者：
Chesney, MA;Barrett, DC;Stall, R
目标。本研究在HIV血清转化方面比较了药物使用史和发作性使用史。对337名基线艾滋病毒阴性的男同性恋者进行了为期8年的跟踪调查。采用双变量分析和生存分析比较39名戒毒人员与非戒毒人员的药物使用行为。吸毒者比非吸毒者更有可能报告使用大麻、亚硝酸盐吸入剂、安非他明和可卡因。持续使用亚硝酸盐吸入剂和安非他明会增加血清转化的相对风险，而间歇性使用则不会。两种可卡因使用模式都增加血清转化风险。由于持续使用药物而增加转化风险的潜在机制有三种。
Objectives. This study compared history of substance use and episodic use in terms of HIV seroconversion.Methods. A sample of 337 baseline HIV-negative gay men was followed for-ti years. Bivariate and survival analyses were used to compare 39 converters with nonconverters on substance use behaviors.Results. Seroconverters were consistently more likely to report use of marijuana, nitrite inhalants, amphetamines, and cocaine than nonconverters. Consistent use of nitrite inhalants and amphetamines increases the relative risk of seroconversion, while episodic use does not. Both patterns of cocaine use increase seroconversion risk.Conclusions. There are three potential mechanisms for an increased risk of conversion due to consistent substance use.