Findings from Left Ventricular Strain and Strain Rate Imaging in Asymptomatic Patients With Type 2 Diabetes Mellitus
Findings from Left Ventricular Strain and Strain Rate Imaging in Asymptomatic Patients With Type 2 Diabetes Mellitus
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DOI：
10.1016/j.amjcard.2009.06.063
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发表时间：
2009-11-15
影响因子：
2.8
通讯作者：
Bax, Jeroen J.
中科院分区：
文献类型：
--
作者：
Ng, Arnold C. T.;Delgado, Victoria;Bax, Jeroen J.
早期糖尿病心肌病的局部左心室(LV)心肌功能改变还没有很好的文献报道。应用二维斑点追踪技术对47例无症状男性2型糖尿病患者进行了左室多向应变和应变率分析，检测了无症状的男性2型糖尿病患者的心肌功能异常。结果与年龄、体重指数和身体表面积匹配的53名男性对照组的结果进行了比较。LV舒张末容量指数(40.7±/-8.9vs44.1+/-7.8ml/m(2)，P=NS)，收缩末期容量指数(16.0±/-4.8vs17.8+/-4.3ml/m(2)，p=NS)，射血分数(61.0+/-5.5%vs59.8+/-5.3%，p=NS)。二尖瓣E/A比值(0.95+/-0.21vs1.12+/-0.32，p=0.007)和肺S/D比值(1.45+/-0.28vs1.25+/-0.27，p=0.001)明显受损。重要的是，糖尿病患者的纵向功能受损，但保留了周向和径向收缩和舒张期功能。多元线性回归分析显示糖尿病是纵向应变、收缩应变率和舒张期应变率的独立预测因子(均P<；0.001)。结论：无合并症2型糖尿病患者的左心室纵向收缩和舒张期功能受损，但周向和径向功能得到保护。(C)2009 Elsevier Inc.保留所有权利。(美国心脏杂志2009；104：1398-1401)
Regional left ventricular (LV) myocardial functional changes in early diabetic cardiomyopathy have not been well documented. LV multidirectional strain and strain rate analyses by 2-dimensional speckle tracking were used to detect subtle myocardial dysfunction in 47 asymptomatic, male patients (age 57 6 years) with type 2 diabetes mellitus. The results were compared to those from 53 male controls matched by age, body mass index, and body surface area. No differences were found in the LV end-diastolic volume index (40.7 +/- 8.9 vs 44.1 +/- 7.8 ml/m(2), P = NS), end-systolic volume index (16.0 +/- 4.8 vs 17.8 +/- 4.3 ml/m(2), p = NS), ejection fraction (61.0 +/- 5.5% vs 59.8 +/- 5.3%, p = NS). The transmitral E/A (0.95 +/- 0.21 vs 1.12 +/- 0.32, p = 0.007) and pulmonary S/D (1.45 +/- 0.28 vs 1.25 +/- 0.27, p = 0.001) ratios were more impaired in the patients with diabetes mellitus. Importantly, the diabetic patients had impaired longitudinal, but preserved circumferential and radial systolic and diastolic, function. Diabetes mellitus was an independent predictor for longitudinal strain, systolic strain rate and early diastolic strain rate on multiple linear regression analysis (all p < 0.001). In conclusion, the LV longitudinal systolic and diastolic function were impaired, but the circumferential and radial functions were preserved in patients with uncomplicated type 2 diabetes mellitus. (c) 2009 Elsevier Inc. All rights reserved. (Am J Cardiol 2009;104: 1398-1401)