NEUROPOIETIC CYTOKINES IN THE HEMATOPOIETIC FOLD
NEUROPOIETIC CYTOKINES IN THE HEMATOPOIETIC FOLD
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DOI：
10.1016/0896-6273(91)90258-2
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发表时间：
1991-08-01
期刊：
影响因子：
16.2
通讯作者：
BAZAN, JF
中科院分区：
文献类型：
--
作者：
BAZAN, JF
在决定交感神经元从去甲肾上腺素能功能到胆碱能功能的发育命运的分子中，有两种明显不相关的蛋白质：胆碱能分化因子和睫状神经营养因子（分别为CDF和CNTF）。目前的工作提出了它们功能重叠的结构基础：序列模式匹配和预测结构分析认为 CDF 和 CNTF 是同源的并且共享共同的螺旋框架。整合的 CDF/CNTF 谱还揭示了一组造血细胞因子中相似的序列/结构基序，这些细胞因子由粒细胞集落刺激因子、白细胞介素 6 和一种称为制瘤素 M 的新因子组成。与白细胞介素3和干扰素α/β的关系更远。神经生成细胞因子和造血细胞因子之间的进化关系预测了未表征的 CDF 和 CNTF 受体的独特三级结构。相互交织的细胞因子/受体网络表明神经和造血的分子机制之间存在更密切的关系。
Among the molecules that determine the developmental fate of sympathetic neurons f rom noradrenergic to cholinergic function are two apparently unrelated proteins, cholinergic differentiation factor and ciliary neurotrophic factor (CDF and CNTF, respectively). The present work suggests a structural basis for their functional overlap: sequence pattern-matching and predictive structure analysis contends that CDF and CNTF are homologous and share a common helical framework. An integrated CDF/CNTF profile also reveals similar sequence/structure motifs in a group of hematopoietic cytokines composed of granulocyte colony-stimulating factor, interleukin-6, and a novel factor called oncostatin M; a more distant relationship is indicated with interleukin-3 and interferons-alpha/beta. Evolutionary ties between neuropoietic and hematopoietic cytokines predict a distinctive tertiary architecture for the uncharacterized CDF and CNTF receptors. The intertwined cytokine/receptor networks signal a closer relationship between the molecular mechanisms underlying neuro- and hematopoiesis.