Correlation between optic disc perfusion and glaucomatous severity in patients with open-angle glaucoma: an optical coherence tomography angiography study
Correlation between optic disc perfusion and glaucomatous severity in patients with open-angle glaucoma: an optical coherence tomography angiography study
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DOI：
10.1007/s00417-015-3095-y
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发表时间：
2015-09-01
影响因子：
2.7
通讯作者：
Sun, Xinghuai
中科院分区：
文献类型：
--
作者：
Wang, Xiaolei;Jiang, Chunhui;Sun, Xinghuai
为探讨开角型青光眼（OAG）患者视盘血流灌注的变化及其与青光眼严重程度的关系，我们对62例62眼OAG患者和20例20眼正常对照者进行了前瞻性横断面观察研究。使用光学相干断层扫描血管造影术（angio-OCT）研究视盘灌注，并测定血流指数和血管密度。记录VF、平均差（MD）、模式标准差（PSD）、视网膜神经纤维层（RNFL）厚度和神经节细胞复合体（GCC）厚度。在OAG患者中，椎间盘血流指数和血管密度显著低于正常对照组（均p < 0.001），并且与青光眼的严重程度相关。在OAG眼中，血流指数和血管密度与MD、RNFL和GCC厚度显著相关（均p < 0.01），但在正常对照组中则无相关性。受试者工作特征（ROC）曲线分析也显示，视盘血流指数和血管密度对正常眼和OAG眼有鉴别力（ROC曲线下分别为0.82和0.80），青光眼患者视盘血流指数和血管密度降低，且与GCC厚度密切相关。这表明通过血管OCT测量椎间盘灌注对于青光眼的监测可能是重要的。
To explore how optic disc perfusion varies in patients with open-angle glaucoma (OAG) and how this correlates with glaucoma severity.We performed a prospective and cross-sectional observational study that included 62 eyes from 62 patients with OAG, divided into three groups according to their visual field (VF) results, and 20 eyes from 20 normal control subjects. Optic disc perfusion was studied using optical coherence tomography angiography (angio-OCT), and flow index and vessel density were determined. The VF, mean deviation (MD), pattern standard deviation (PSD), retinal nerve fiber layer (RNFL) thickness, and ganglion cell complex (GCC) thickness were also recorded. The potential associations between disc perfusion and VF defects or structural loss were analyzed.In OAG patients, the disc flow index and vessel density were significantly lower than in normal controls (all p < 0.001) and were correlated with the severity of glaucoma. In OAG eyes, the flow index and vessel density were significantly correlated with MD, RNFL, and GCC thickness (all p < 0.01), but were not in the normal controls. The receiver operating characteristic (ROC) curve analysis also revealed that disc flow index and vessel density had the power to differentiate normal eyes from eyes with OAG (under the ROC curves: 0.82 and 0.80, respectively).Angiograms demonstrated a reduced disc flow index and vessel density in glaucoma, and this reduction was closely related to GCC thickness. This indicated that measurement of disc perfusion by angio-OCT might be important for the monitoring of glaucoma.