The WWWH of remote homolog detection: The state of the art
The WWWH of remote homolog detection: The state of the art
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DOI：
10.1093/bib/bbl032
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发表时间：
2007-03-01
影响因子：
9.5
通讯作者：
Casadio, Rita
中科院分区：
文献类型：
--
作者：
Fariselli, Piero;Rossi, Ivan;Casadio, Rita
利用计算方法检测蛋白质的远程同源对是结构生物信息学中的一个关键问题，其目的是根据已知结构数据库中的信息计算蛋白质折叠。在过去的25年里，已经开发了几种方法来解决这个问题，基于不同的方法，包括序列比对和/或结构比较。在本文中，我们将简要讨论何时、为何、何地和如何（WWWH）执行远程同源搜索，回顾一些最广泛采用的计算方法。具体目的是突出不同研究小组实施的基本标准，并评论艺术的现状以及仍然开放的问题。
The detection of remote homolog pairs of proteins using computational methods is a pivotal problem in structural bioinformatics, aiming to compute protein folds on the basis of information in the database of known structures. In the last 25 years, several methods have been developed to tackle this problem, based on different approaches including sequence-sequence alignments and/or structure comparison. In this article, we will briefly discuss When, Why, Where and How (WWWH) to perform remote homology search, reviewing some of the most widely adopted computational approaches. The specific aim is highlighting the basic criteria implemented by different research groups and commenting on the status of the art as well as on still-open questions.