Pathoclysis in aging human cerebral cortex: Evidence from in vivo MRI morphometry
Pathoclysis in aging human cerebral cortex: Evidence from in vivo MRI morphometry
复制标题
衰老人类大脑皮层的病理溶解：来自体内 MRI 形态测量的证据
DOI：
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发表时间：
1993
期刊：
影响因子：
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通讯作者：
J. Acker
中科院分区：
文献类型：
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作者：
N. Raz;I. Torres;W. D. Spencer;J. Acker
在选定的皮质区域的横截面积和体积的脑相关的差异进行了检查，使用在体内磁共振形态测量。在两个样本中健康志愿者和放射学检查结果阴性的患者出现了类似的皮质老化模式。联合皮层取样区域的大小与年龄呈负相关，而感觉皮层的大小与年龄之间没有显着的相关性被发现。在第一个样本中，但不是第二个样本，一些相关性减弱后，头骨大小和性别的统计控制。总体而言，观察到白色物质的不对称性和灰质的不对称性的小但一致的趋势。报告的研究结果支持的概念，伴随着感觉皮层的相对保留的皮质关联区的选择性老化。
Age-related differences in the cross-sectional area and volume of selected cortical regions were examined by using in vivo magnetic resonance morphometry. In two samples—healthy volunteers and patients with negative radiological findings—similar patterns of cortical aging emerged. The size of sampled regions of association cortices correlated negatively with age, whereas no significant correlations between the size of sensory cortices and age were found. In the first but not the second sample, some of the correlations were attenuated after statistical control for skull size and sex. Overall, small but consistent trends for leftward asymmetry of the white matter and rightward asymmetry of the gray matter were observed. The results of the reported studies support the notion of selective aging of cortical association areas accompanied by relative sparing of sensory cortices.
影响因子：
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作者：
Terry L. Jernigan;G. Press;J. Hesselink
通讯作者：
Terry L. Jernigan;G. Press;J. Hesselink