Revisiting normal 51Cr-ethylenediaminetetraacetic acid clearance values in children
Revisiting normal 51Cr-ethylenediaminetetraacetic acid clearance values in children
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DOI：
10.1007/s00259-006-0179-2
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发表时间：
2006-12-01
影响因子：
9.1
通讯作者：
Ham, H.
中科院分区：
文献类型：
--
作者：
Piepsz, A.;Tondeur, M.;Ham, H.
目的：正常cr -51-乙二胺四乙酸（EDTA）清除率作为年龄的函数数年前发表。这些数值是基于患儿的数据，患儿的左右比例正常，尽管存在急性肾脏感染，但DMSA显像上表现正常。当时，作者没有意识到超滤是急性肾感染患者的常见现象，其正常值可能被严重高估。因此，目前的工作旨在重新评估这些正常值。方法：第一步，为了验证之前的结果，选择相同类型的人群，即目前或过去尿路感染但图像正常且DMSA闪烁成像左右比例正常的患者。在第二步中，选择基于近期没有尿路感染的患者。在这两个系列中，采用单血样法评估Cr-51-EDTA清除。结果：在第一组患者中，获得的结果与先前发表的结果几乎相同。在第二组患者中，结果明显较低：2岁后，GFR平均值为104 ml/min/ 1.73 m(2)（第10和90百分位分别为81和135 ml/min/ 1.73 m(2)），而第一组为117 ml/min/ 1.73 m(2)。结论：第二组的数据可能更能代表真实的正常GFR值，可以应用于整个儿科人群。
Purpose: Normal Cr-51-ethylenediaminetetraacetic acid ( EDTA) clearance values as a function of age were published a number of years ago. These values were based on data from children with a normal left to right ratio and a normal appearance on DMSA scintigraphy, despite the presence of an acute renal infection. At that time, the authors were unaware that hyperfiltration is a common phenomenon in patients with acute renal infection and that their normal values could have been significantly overestimated. The present work therefore aimed to re-appraise these normal values.Methods: In a first step, in order to verify the previous results, the same type of population was selected, namely patients with present or past urinary tract infection but normal images and a normal left to right ratio on DMSA scintigraphy. In a second step, the selection was based on patients who had had no recent urinary tract infection. In both series, a single blood sample method was used for the evaluation of Cr-51-EDTA clearance.Results: In the first group of patients, the results obtained were almost identical to those previously published. In the second group of patients, the results were significantly lower: after 2 years of age, the mean GFR value was 104 ml/min/ 1.73 m(2) ( 10th and 90th percentiles 81 and 135 ml/min/ 1.73 m(2), respectively), compared with 117 ml/ min/1.73 m(2) in the first group.Conclusion: The data of the second group are probably more representative of the true normal GFR values and can be applied to the entire paediatric population.