Movement Disorder Society-Sponsored Revision of the Unified Parkinson's Disease Rating Scale (MDS-UPDRS): Scale Presentation and Clinimetric Testing Results
Movement Disorder Society-Sponsored Revision of the Unified Parkinson's Disease Rating Scale (MDS-UPDRS): Scale Presentation and Clinimetric Testing Results
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DOI：
10.1002/mds.22340
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发表时间：
2008-11-15
影响因子：
8.6
通讯作者：
LaPelle, Nancy
中科院分区：
文献类型：
--
作者：
Goetz, Christopher G.;Tilley, Barbara C.;LaPelle, Nancy
我们提出了由运动障碍协会(MDS)赞助修订的统一帕金森病评定量表(MDS-UPDRS)的临床测量评估。MDS-UDPRS工作队利用发表的评论中的建议修订和扩大了UPDRS。MDS-UPDRS包括4个部分，即1：非运动日常生活体验；11：日常生活运动体验；III：运动检查；IV：运动并发症。20个问题由患者/照顾者完成。提供了具体项目的说明和补充补充额度表的附录。运动障碍专家和研究协调员对来自39个地点的877名说英语(78%非拉丁裔高加索人)的帕金森病患者进行了UPDRS(55个条目)和MDS-UPDRS(65个条目)的测试。采用相关技术和因子分析对两个量表进行比较。MDS-UPDRS具有较高的内部一致性(Cronbach‘sα0.79~0.93)，并与原始UPDRS相关(Rho=0.96)。MDS-UPDRS的跨部分相关性在0.22到0.66之间。得到了每个部分的可靠因素结构(每个部分的比较匹配指数为0.90)，这支持使用每个部分的总分而不是所有部分的总分。本研究的综合临床测量结果支持MDS-UPDRS对PD进行分级的有效性。(C)2008年流动无序社会
We present a clinimetric assessment of the Movement Disorder Society (MDS)-sponsored revision of the Unified Parkinson's Disease Rating Scale (MDS-UPDRS). The MDS-UDPRS Task Force revised and expanded the UPDRS using recommendations from a published critique. The MDS-UPDRS has four parts, namely, 1: Non-motor Experiences of Daily Living; 11: Motor Experiences of Daily Living; III: Motor Examination; IV: Motor Complications. Twenty questions are completed by the patient/caregiver. Item-specific instructions and an appendix of complementary additional scales are provided. Movement disorder specialists and Study coordinators administered the UPDRS (55 items) and MDS-UPDRS (65 items) to 877 English speaking (78% non-Latino Caucasian) patients with Parkinson's disease from 39 sites. We compared the two scales using correlative techniques and factor analysis. The MDS-UPDRS showed high internal consistency (Cronbach's alpha 0.79-0.93 across parts) and correlated with the original UPDRS (rho = 0.96). MDS-UPDRS across-part correlations ranged from 0.22 to 0.66. Reliable factor structures for each part were obtained (comparative fit index > 0.90 for each part), which support the use of sum scores for each part in preference to a total score of all parts. The combined clinimetric results of this study support the validity of the MDS-UPDRS for rating PD. (C) 2008 Movement Disorder Society