Leukoaraiosis Burden Significantly Modulates the Association Between Infarct Volume and National Institutes of Health Stroke Scale in Ischemic Stroke
Leukoaraiosis Burden Significantly Modulates the Association Between Infarct Volume and National Institutes of Health Stroke Scale in Ischemic Stroke
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DOI：
10.1161/strokeaha.115.009258
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发表时间：
2015-07-01
期刊：
影响因子：
8.3
通讯作者：
Henninger, Nils
中科院分区：
文献类型：
--
作者：
Helenius, Johanna;Henninger, Nils
背景和目的美国国立卫生研究院卒中量表（NIHSS）提供了一种可靠的、定量的缺血性卒中严重程度的测量方法，并通过梗死面积来预测。我们试图确定白质病变严重程度是否影响梗死面积和NIHSS之间的关系。方法对312例幕上缺血性脑卒中患者的NIHSS和弥散加权成像确定的梗死体积进行分析。根据Fazekas量表对白质病变严重程度进行分级，概念上定义为无（0,n=44）、轻度（1-2,n=106）、中度（3-4,n=105）和重度（5-6,n=57）。ANCOVA用于描述白化对梗死面积和NIHSS之间关系的影响。构建多变量线性回归模型来评估NIHSS白质变与梗死体积的关联是否独立于其他临床相关协变量。结果总体而言，梗死面积与NIHSS有显著相关性(r=0.591
Background and Purpose The National Institutes of Health Stroke Scale (NIHSS) provides a reliable, quantitative measure of ischemic stroke severity and is predicted by the infarct size. We sought to determine whether leukoaraiosis severity affects the association between infarct size and NIHSS.Methods NIHSS and diffusion-weighted imaging-defined infarct volumes from 312 prospectively enrolled patients with supratentorial, ischemic strokes were analyzed. Leukoaraiosis severity was graded according to the Fazekas scale and conceptually defined as absent (0; n=44), mild (1-2; n=106), moderate (3-4; n=105), and severe (5-6; n=57). ANCOVA was used to describe the effect of leukoaraiosis on the association between infarct volume and NIHSS. Multivariable linear regression models were constructed to assess whether the association of leukoaraiosis and infarct volume on NIHSS was independent of other clinically relevant covariates.Results Overall, there was a significant correlation between the infarct volume and NIHSS (r=0.591; P