Tetrahydrobiopterin in striatum: localization in dopamine nerve terminals and role in catecholamine synthesis.
Tetrahydrobiopterin in striatum: localization in dopamine nerve terminals and role in catecholamine synthesis.
复制标题
纹状体中的四氢生物蝶呤：多巴胺神经末梢的定位及其在儿茶酚胺合成中的作用。
作者：
R. Levine;L. Miller;W. Lovenberg
羟基酶辅因子四氢生物蝶呤及其生物合成系统定位于纹状体的多巴胺能神经末梢。这一结论是基于在黑质注射6-羟基多巴胺后，酪氨酸羟基酶和四氢生物蝶呤及其生物合成酶鸟苷三磷酸环水解酶的损失几乎相等。羟基酶辅助因子在调节多巴胺合成中的作用被重新评估。
The hydroxylase cofactor, tetrahydrobiopterin, and its biosynthetic system are localized in dopaminergic nerve terminals in the striatum. This conclusion is based on the nearly equivalent loss of tyrosine hydroxylase and tetrahydrobiopterin and its initial biosynthetic enzyme, guanosine triphosphate cyclohydrolase, after injection of 6-hydroxydopamine into the substantia nigra. The role of the hydroxylase cofactor in the regulation of dopamine synthesis is reassessed.