CHROMOSOME-ABERRATIONS IN MAMMALIAN-CELLS EXPOSED TO VITAMIN-C AND MULTIPLE VITAMIN PILLS
CHROMOSOME-ABERRATIONS IN MAMMALIAN-CELLS EXPOSED TO VITAMIN-C AND MULTIPLE VITAMIN PILLS
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DOI：
10.1016/0015-6264(80)90164-9
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发表时间：
1980-01-01
期刊：
影响因子：
--
通讯作者：
WHITING, RF
中科院分区：
文献类型：
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作者：
STICH, HF;WEI, L;WHITING, RF
测试了三种不同抗坏血酸含量的多种维生素片剂、三种含有合成或天然抗坏血酸的维生素C丸剂、7种强化铁的多种维生素片剂和维生素C丸剂加铁补充剂诱导培养的中国仓鼠卵巢细胞染色体畸变的能力。所有这些市售维生素药丸都会引起染色体断裂和交换。所检查的药丸的活性稀释范围和诱导的染色体损伤程度各不相同。观察到的具有染色体畸变的中期板的频率高达 42%。
Three multiple vitamin tablets with different ascorbic acid contents, 3 vitamin C pills with a synthetic or natural source of ascorbic acid, 7 Fe-fortified multiple vitamin tablets and vitamin C pills plus Fe supplement were tested for their capacity to induce chromosome aberrations in cultured Chinese hamster ovary cells. All of these commercially available vitamin pills induced chromosome breaks and exchanges. The active dilution range and the extent of chromosome damage induced varied among the pills examined. The observed frequencies of metaphase plates with chromosome aberrations ranged up to 42%.