COPD in Japan: The Nippon COPD Epidemiology Study
COPD in Japan: The Nippon COPD Epidemiology Study
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DOI：
10.1111/j.1440-1843.2004.00637.x
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发表时间：
2004-11-01
期刊：
影响因子：
6.9
通讯作者：
Zaher, C
中科院分区：
文献类型：
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作者：
Fukuchi, Y;Nishimura, M;Zaher, C
目的：尽管吸烟率高，但在亚洲进行的COPD患病率研究很少。Nippon COPD Epidemiology（NICE）Study使用肺量测定法测量日本成人气流受限的患病率。方法：收集了2343例年龄≥ 40岁的受试者的临床、肺量测定和危险因素暴露数据，这些受试者在人口统计学上与日本人群相似。根据全球慢性阻塞性肺疾病倡议（GOLD）标准定义气流受限（FEV 1，FVC < 70%）。根据GOLD严重程度标准，发现这些病例中有56%为轻度，38%为中度，5%为重度，1%为极重度。气流限制在男性中的发生率明显高于女性（16.4%比5.0%; P < 0.001），在男性曾吸烟者中的发生率明显高于女性（17.1%比7.5%; P < 0.001），在老年受试者中（40-49岁受试者为3.5%，> 70岁受试者为24.4%; P < 0.001）。值得注意的是，在5.8%的非吸烟者和4.6%的60岁以下人群中也发现了气流限制。只有9.4%的情况下，气流限制报告以前的诊断COPD.Conclusions：在日本的气流限制的患病率高于以前的报道，这表明了高度的认识不足的COPD。吸烟的高患病率加上人口老龄化可能会进一步增加COPD的负担，突出表明需要加强筛查工作和预防和治疗干预措施。
Objectives: Despite high smoking rates, few prevalence studies of COPD have been performed in Asia. The Nippon COPD Epidemiology (NICE) Study used spirometry to measure prevalence of airflow limitation in Japanese adults.Methodology: Clinical, spirometric, and risk factor exposure data were collected on 2343 subjects aged >= 40 years who were demographically similar to the Japanese population. Airflow limitation was defined according to Global Initiative for Chronic Obstructive Lung Disease (GOLD) criteria (FEV1, FVC < 70%).Results: Prevalence of airflow limitation was 10.9%. Based upon GOLD severity criteria, 56% of these cases were found to be mild, 38% moderate, 5% severe, and 1% very severe. Airflow limitation was significantly more prevalent in males than females (16.4% vs. 5.0%; P < 0.001), in male ever-smokers than female ever-smokers (17.1% vs. 7.5%; P < 0.001), and in older subjects (3.5% in 40-49 years olds vs. 24.4% in those > 70 years; P < 0.001). Of note, airflow limitation was also found in 5.8% of non-smokers and 4.6% of those younger than age 60 years. Only 9.4% of cases with airflow limitation reported a previous diagnosis of COPD.Conclusions: Prevalence of airflow limitation in Japan is higher than previously reported, suggesting a high degree of under-recognition of COPD. The high prevalence of smoking coupled with an aging population threatens to further increase the burden of COPD, highlighting the need for enhanced screening efforts and interventions of prevention and treatment.