Phosphine-catalyzed sequential (2+3)/(2+4) annulation of γ-vinyl allenoates: access to the synthesis of chromeno[4,3-b]pyrroles
Phosphine-catalyzed sequential (2+3)/(2+4) annulation of γ-vinyl allenoates: access to the synthesis of chromeno[4,3-b]pyrroles
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膦催化的γ-乙烯基联烯酸酯的连续 (2 3)/(2 4) 环化：获得色并[4,3-b]吡咯的合成
DOI：
10.1039/d1cc04199a
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发表时间：
2021-09-02
影响因子：
4.9
通讯作者：
Huang, You
中科院分区：
文献类型：
--
作者：
Li, Xiaohu;Huang, You
采用膦催化-乙烯烯丙酸酯与醛二胺酯的级联(2+3)/(2+4)环化反应，得到了一系列含有三个连续立体中心的色[4,3-b]吡咯衍生物。该方法产率高，在温和条件下具有良好的化学选择性和非对映选择性。
A phosphine-catalyzed cascade (2+3)/(2+4) cyclization reaction of gamma-vinyl allenoates with aldimine esters has been developed to provide a series of chromeno[4,3-b]pyrrole derivatives that contain three contiguous stereogenic centers. The method gives a good yield, excellent chemoselectivity and diastereoselectivity under mild conditions.