Association between consumption frequency of honey and non-alcoholic fatty liver disease: results from a cross-sectional analysis based on the Tianjin Chronic Low-grade Systemic Inflammation and Health (TCLSIH) Cohort Study
Association between consumption frequency of honey and non-alcoholic fatty liver disease: results from a cross-sectional analysis based on the Tianjin Chronic Low-grade Systemic Inflammation and Health (TCLSIH) Cohort Study
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DOI：
10.1017/s0007114520003190
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发表时间：
2021-03-28
影响因子：
3.6
通讯作者：
Niu, Kaijun
中科院分区：
文献类型：
--
作者：
Zhang, Shunming;Wu, Xiaohui;Niu, Kaijun
非酒精性脂肪性肝病（NAFLD）是代谢综合征的肝脏表现。最近的证据表明，蜂蜜消费对代谢综合征有保护作用，但蜂蜜摄入量与NAFLD之间的关系仍不清楚。我们调查了蜂蜜的消费频率如何与一般人群中的NAFLD相关。这是一项对21979名年龄在20-90岁之间的成年人进行的横断面研究。根据超声诊断脂肪肝，无明显酒精摄入和其他肝脏疾病，诊断NAFLD。饮食信息，包括蜂蜜的消费频率，通过验证的100项FFQ进行评估。通过二元逻辑回归模型计算OR和95%CI，调整有向非循环图确定的混杂因素。总体而言，6513名成人（29中心点6%）患有NAFLD。与消费= 1次/d的参与者相比（趋势P = 0，中心点90）。在临界点为24中心点0 kg/m2的BMI亚组中，结果基本相似（相互作用P = 0中心点10）。在这项大规模研究中，每周食用2-6次蜂蜜与NAFLD呈负相关，而每天食用蜂蜜>= 1次与NAFLD无关。这些结果需要在其他大规模前瞻性研究中复制。
Non-alcoholic fatty liver disease (NAFLD) is the hepatic manifestation of the metabolic syndrome. Recent evidence has suggested the protective effects of honey consumption against the metabolic syndrome, but the association between honey intake and NAFLD is still unclear. We investigated how the consumption frequency of honey was associated with NAFLD in the general population. This was a cross-sectional study of 21 979 adults aged 20-90 years. NAFLD was diagnosed based on the ultrasound-diagnosed fatty liver without significant alcohol intake and other liver diseases. Diet information, including consumption frequency of honey, was assessed by a validated 100-item FFQ. OR with 95 % CI were calculated by the binary logistic regression model, adjusting for confounding factors identified by the directed acyclic graph. Overall, 6513 adults (29 center dot 6 %) had NAFLD. Compared with participants consuming = 1 times/d (P-for trend = 0 center dot 90). The results were generally similar in subgroups of BMI at a cut-point of 24 center dot 0 kg/m(2) (P-for interaction = 0 center dot 10). In this large-scale study, consuming honey 2-6 times/week was inversely associated with NAFLD, whereas consuming honey >= 1 times/d had no association with NAFLD. These results need replication in other large-scale prospective studies.