Ionoacoustic tomography of the proton Bragg peak in combination with ultrasound and optoacoustic imaging.
Ionoacoustic tomography of the proton Bragg peak in combination with ultrasound and optoacoustic imaging.
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DOI：
10.1038/srep29305
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发表时间：
2016-07-07
影响因子：
4.6
通讯作者：
Ntziachristos V
中科院分区：
文献类型：
--
作者：
Kellnberger S;Assmann W;Lehrack S;Reinhardt S;Thirolf P;Queirós D;Sergiadis G;Dollinger G;Parodi K;Ntziachristos V
对于外束放射治疗，离子提供了比光子更有利的剂量分布，这是由于其所谓的反深度剂量沉积，特别是在其射程末端(布拉格峰)具有特征的剂量最大值。良好的物理相互作用特性使肿瘤能够选择性治疗，同时保留周围的健康组织，但最佳的临床使用需要准确监测布拉格峰在组织内的位置。我们介绍了基于离子诱导超声波探测的离子声波层析成像技术，作为一种提供关于离子束轮廓的反馈的技术。对于20 MeV的质子，我们证明了离子范围成像是可能的，具有亚毫米的精度，并且可以与类似精度的临床超声和光声断层成像相结合。我们的结果表明，在体内和实时地将肿瘤区域的常规超声回波与电离声断层成像相关联是一种简单而直接的可能性。与光声断层成像相结合，它提供了一个非常适合临床前的成像系统。
Ions provide a more advantageous dose distribution than photons for external beam radiotherapy, due to their so-called inverse depth dose deposition and, in particular a characteristic dose maximum at their end-of-range (Bragg peak). The favorable physical interaction properties enable selective treatment of tumors while sparing surrounding healthy tissue, but optimal clinical use requires accurate monitoring of Bragg peak positioning inside tissue. We introduce ionoacoustic tomography based on detection of ion induced ultrasound waves as a technique to provide feedback on the ion beam profile. We demonstrate for 20 MeV protons that ion range imaging is possible with submillimeter accuracy and can be combined with clinical ultrasound and optoacoustic tomography of similar precision. Our results indicate a simple and direct possibility to correlate, in-vivo and in real-time, the conventional ultrasound echo of the tumor region with ionoacoustic tomography. Combined with optoacoustic tomography it offers a well suited pre-clinical imaging system.